{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cilia‐ and flagella‐associated protein 210 (CFAP210) has been identified as a component of the protein complement of the human airway ciliary axoneme, suggesting a role in the assembly and/or stabilization of the ciliary structure that is essential for proper ciliary motility and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, a large‐scale mRNA expression study comparing brain frontal cortex samples from various domesticated animal species and their wild counterparts did not highlight CFAP210 among the differentially expressed genes associated with behavioral or morphological changes during domestication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This suggests that while CFAP210 appears to play a specialized role in cilia‐related processes, particularly in the context of axonemal composition and potentially in mucociliary clearance or signaling pathways, it is unlikely to be a major contributor to the gene expression signatures that underpin behavioral domestication traits.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kevin Blackburn, Ximena Bustamante-Marin, Weining Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.6b00972"}], "href": "https://doi.org/10.1021/acs.jproteome.6b00972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28282151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28282151"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Frank W Albert, Mehmet Somel, Miguel Carneiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comparison of brain gene expression levels in domesticated and wild animals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002962"}], "href": "https://doi.org/10.1371/journal.pgen.1002962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23028369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23028369"}]}]}]}