{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CFAP298‐TCP10L appears to represent a chimeric transcript generated through alternative splicing or fusion events that can impact gene essentiality in cancer. In one study, a large‐scale platform (TranscriptAchilles) was used to integrate loss‐of‐function screens and transcriptome profiling to identify transcript isoforms that serve as biomarkers for gene essentiality. Although CFAP298‐TCP10L was not explicitly discussed as a canonical oncogene, its inclusion in such analyses suggests that its aberrant splicing could influence tumor cell dependencies and thereby provide a starting point for therapeutic target discovery."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a complementary study, genome‐wide profiling of chimeric RNAs in non‐diseased human tissues demonstrated that transcripts like CFAP298‐TCP10L occur not only in cancer but also in normal cells, underscoring the need to distinguish between disease‐specific aberrations and naturally occurring fusion events when considering functional relevance and biomarker potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that CFAP298‐TCP10L may play a dual role—acting as a functional marker within the deregulated splicing landscapes of cancer and as part of the broader repertoire of chimeric RNAs present under physiological conditions—highlighting its promise for further investigation in both precision medicine and the study of gene regulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fernando Carazo, Lucía Campuzano, Xabier Cendoya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TranscriptAchilles: a genome-wide platform to predict isoform biomarkers of gene essentiality in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gigascience (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/gigascience/giz021"}], "href": "https://doi.org/10.1093/gigascience/giz021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30942869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30942869"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sandeep Singh, Fujun Qin, Shailesh Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The landscape of chimeric RNAs in non-diseased tissues and cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz1223"}], "href": "https://doi.org/10.1093/nar/gkz1223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31965184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31965184"}]}]}]}