{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have begun to shed light on the role of CFAP95—also known by its alternative gene name C9ORF135—in human stem cell biology and cancer. In undifferentiated human embryonic stem cells (hESCs), CFAP95 encodes a membrane‐associated protein whose expression is tightly regulated by pluripotency factors such as OCT4 and SOX2. Notably, its expression is robust in undifferentiated hESCs and is sharply downregulated during gastrulation and gametogenesis, suggesting that CFAP95 may serve as a surface marker for the stem cell state and could play a role in maintaining cell architecture through its interactions with cytoskeletal effectors like non‐muscle myosin IIA and IIB."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its function in early developmental processes, CFAP95 has emerged as a candidate biomarker in cancer. For instance, in clear cell renal cell carcinoma, CFAP95 (among other genes) was identified as being significantly related to patient prognosis, suggesting that changes in its expression may reflect underlying alterations in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, differential co-expression analyses in lung cancer have revealed CFAP95 as part of gene pairs whose altered correlation patterns may underlie aspects of tumor development and cell adhesion dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that CFAP95/C9ORF135 is not only a marker of pluripotency in hESCs—with potential roles in cellular adhesion and cytoskeletal organization—but also may contribute to cancer progression and serve as a prognostic indicator in certain tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shixin Zhou, Yinan Liu, Yumin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep45311"}], "href": "https://doi.org/10.1038/srep45311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28345668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28345668"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zedan Zhang, Enyu Lin, Hongkai Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a novel gene-based model for prognosis prediction of clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-1113-6"}], "href": "https://doi.org/10.1186/s12935-020-1113-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32002016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32002016"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiu Lan, Weilong Lin, Yufen Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The detection and analysis of differential regulatory communities in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2020.02.005"}], "href": "https://doi.org/10.1016/j.ygeno.2020.02.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32045668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32045668"}]}]}]}