{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCFAP96—previously referenced as C4orf47—is implicated in the adaptation of cancer cells to hypoxic conditions within the tumor microenvironment. Research indicates that under low-oxygen stress, CFAP96 expression becomes up-regulated, a change that has been associated with the induction of a dormant state in cancer cells. This dormancy may contribute to tumor persistence and resistance to standard therapies, as observed in gallbladder cancer and similar solid tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe enhanced expression of CFAP96 under hypoxia suggests that it could be involved in modulating key signaling pathways that support cell survival and adaptation during metabolic stress. In pancreatic cancer, for instance, a similar up-regulation of CFAP96 has been linked to cellular dormancy, highlighting its potential role in the phenotypic shift that enables cancer cells to withstand adverse microenvironmental conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese findings underscore the potential of CFAP96 as a novel therapeutic target, particularly for refractory cancers like gallbladder cancer. By modulating CFAP96 activity, future treatments might disrupt the hypoxia-induced survival pathways and overcome dormancy-associated resistance, thus enhancing the efficacy of targeted anti-cancer therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Na, Shogo Masuda, Shinjiro Nagao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C4orf47 Contributes to the Induction of Stem-like Properties in Gallbladder Cancer Under Hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/anticanres.16352"}], "href": "https://doi.org/10.21873/anticanres.16352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37097647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37097647"}]}]}]}