{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cfap97d1 is an evolutionarily conserved gene that is exclusively expressed in the testes beginning around post‐natal day 20 and persisting throughout adulthood. Functional studies in knockout mouse models have demonstrated that Cfap97d1 is essential for maintaining the ultrastructural integrity of the sperm flagellum. Specifically, the loss of Cfap97d1 disrupts proper axonemal assembly by causing a frequent loss of the fourth microtubule doublet, which in turn leads to abnormal sperm motility characterized by anti‐hook stalling and asthenozoospermia. This flagellar defect results in compromised fertilization, as shown by reduced embryo formation in vitro with cumulus-intact oocytes despite near-normal fertilization rates with zona pellucida-free oocytes. These findings highlight the critical role of Cfap97d1 in ensuring proper sperm function and male fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, large-scale genetic and proteomic studies have underscored the importance of systematically characterizing unannotated genes to better understand complex biological processes, including aspects of metabolism, lipid regulation, and protein expression in various tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seiya Oura, Samina Kazi, Audrey Savolainen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1008954"}], "href": "https://doi.org/10.1371/journal.pgen.1008954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32785227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32785227"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elisabeth M van Leeuwen, Lennart C Karssen, Joris Deelen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7065"}], "href": "https://doi.org/10.1038/ncomms7065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25751400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25751400"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jan Rozman, Birgit Rathkolb, Manuela A Oestereicher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of genetic elements in metabolism by high-throughput mouse phenotyping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-01995-2"}], "href": "https://doi.org/10.1038/s41467-017-01995-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29348434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29348434"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Omer Siddiqui, Hongjiu Zhang, Yuanfang Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosome 17 Missing Proteins: Recent Progress and Future Directions as Part of the neXt-MP50 Challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.8b00442"}], "href": "https://doi.org/10.1021/acs.jproteome.8b00442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30280577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30280577"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Juniper A Lake, Michael B Papah, Behnam Abasht "}, {"type": "b", "children": [{"type": "t", "text": "Increased Expression of Lipid Metabolism Genes in Early Stages of Wooden Breast Links Myopathy of Broilers to Metabolic Syndrome in Humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes10100746"}], "href": "https://doi.org/10.3390/genes10100746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31557856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31557856"}]}]}]}