{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have demonstrated that the long non‐coding RNA CHL1‐AS1 plays an oncogenic role in gynecologic disorders. In endometriosis, CHL1‑AS1 is found to be enriched in exosomes secreted by peritoneal macrophages and is transferred to ectopic endometrial stromal cells, where it functions as a competing endogenous RNA to sponge miR‑610. This mechanism results in the upregulation of MDM2, thereby promoting cell proliferation, migration, invasion, and suppressing apoptosis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In ovarian endometriosis, CHL1‑AS1 expression is tightly correlated with that of its sense gene CHL1, suggesting that these transcripts may act synergistically in the disease pathogenesis. Bioinformatic and experimental analyses have confirmed that both transcripts are significantly upregulated in ectopic endometrial tissues compared to eutopic counterparts and normal tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in endometrial cancer, CHL1‑AS1 is similarly upregulated together with CHL1. Functional studies indicate that CHL1‑AS1 supports cancer progression by modulating the miR‑6076/CHL1 axis: its knockdown diminishes cell proliferation and migration, effects which can be partially reversed by either loss of miR‑6076 or overexpression of CHL1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although investigations into other long non‑coding RNAs in hepatocellular carcinoma highlight the broad importance of lncRNAs in tumor biology"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the collective findings on CHL1‑AS1 emphasize its potential as a therapeutic target in managing endometriosis and endometrial cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ting Liu, Mei Liu, Caihua Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Nanomedicine (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJN.S323671"}], "href": "https://doi.org/10.2147/IJN.S323671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34408418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34408418"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chen Zhang, Wei Wu, Xue Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2019.03.020"}], "href": "https://doi.org/10.1016/j.ejogrb.2019.03.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30943448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30943448"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanmei Shi, Jinfen Zha, Manzhen Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29486"}], "href": "https://doi.org/10.1002/jcb.29486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31736153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31736153"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Meiyu Dai, Siyuan Chen, Xiaomou Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnosis, prognosis and bioinformatics analysis of lncRNAs in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.21329"}], "href": "https://doi.org/10.18632/oncotarget.21329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29221168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29221168"}]}]}]}