{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CHL1‐AS2 is a long non‐coding RNA that has been shown to be co‐expressed with the CHL1 gene in ovarian endometriosis, where both molecules are significantly upregulated in ectopic endometrial tissues compared with eutopic and normal tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this context, the marked positive correlation between CHL1‐AS2 and CHL1 suggests that CHL1‐AS2 may be part of a regulatory network that influences cellular adhesion and tissue remodeling processes involved in the development of ovarian endometriosis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While the specific functional details of CHL1‐AS2 have been principally investigated in ovarian endometriosis (1), research on long non‑coding RNAs in general has revealed their broader roles as competing endogenous RNAs (ceRNAs). Studies in rectal adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "have highlighted that lncRNAs can function as key regulators of gene expression by sequestering microRNAs and modulating downstream messenger RNAs. In addition, the emerging exploration of lncRNAs in the context of endometriosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "supports the concept that CHL1‐AS2 could also participate in similar ceRNA networks, thereby influencing pathogenic processes such as cellular proliferation, migration, and adhesion.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the potential importance of CHL1‐AS2 in the development of ovarian endometriosis, possibly through the modulation of CHL1 activity and integration into broader lncRNA‐mediated ceRNA regulatory frameworks.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Zhang, Wei Wu, Xue Ye, et al. 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