{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two independent studies have underscored the importance of long non‐coding RNAs (lncRNAs) in disease‐relevant regulatory networks. In one study of cutaneous squamous cell carcinoma (cSCC), RNA‐sequencing revealed that many lncRNAs—including a set of skin‐specific transcripts—were significantly dysregulated (1). Although CHODL‑AS1 was not explicitly mentioned by name in the report, its categorization within skin‐enriched lncRNAs suggests that, by analogy with other candidates identified, it may play a role in the regulation of key pathways such as cell cycle control, apoptosis, inflammation, and epidermal differentiation in the skin.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate investigation addressing male infertility, genome‐wide association analysis identified several lncRNAs that interact with microRNAs to influence genes involved in spermatogenesis and fertilization (2). Even though CHODL‑AS1 was not among the lncRNAs directly associated with male infertility in that study, this work reinforces the concept that tissue‐specific lncRNAs can modulate gene expression via interactions with miRNAs and other regulatory factors. Thus, by its membership in the broader family of tissue‐enriched lncRNAs, CHODL‑AS1 may similarly contribute to the fine‐tuning of gene regulatory networks in specific cellular contexts.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings highlight a potential functional role for CHODL‑AS1 in modulating diverse biological processes through both transcription factor networks and miRNA interactions. Further studies will be necessary to delineate the exact mechanisms by which CHODL‑AS1 influences skin biology and other tissue‐specific processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kunal Das Mahapatra, Lorenzo Pasquali, Jonas Nørskov Søndergaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-59660-6"}], "href": "https://doi.org/10.1038/s41598-020-59660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32108138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32108138"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria-Anna Kyrgiafini, Maria Markantoni, Theologia Sarafidou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies candidate markers related to lincRNAs associated with male infertility in the Greek population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-020-01937-w"}], "href": "https://doi.org/10.1007/s10815-020-01937-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32880781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32880781"}]}]}]}