{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe primate‐specific long noncoding RNA CHROMR is robustly induced by influenza A virus and SARS‑CoV‑2 infections, and plays a critical role in orchestrating the antiviral innate immune response. In human macrophages, CHROMR promotes the expression of interferon‑stimulated genes (ISGs) by enhancing histone acetylation at ISG regulatory regions, a modification that is essential for initiating effective transcriptional responses to microbial challenges. This lncRNA thereby sustains a protective cellular state against viral infections by ensuring that key antiviral genes are properly activated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, CHROMR functions by sequestering IRF2BP2, an interferon regulatory factor‑2‑dependent transcriptional corepressor that normally restrains IRF‑mediated signaling. By binding to and inhibiting IRF2BP2, CHROMR licenses the full activation of IRF‐dependent transcription of the ISG network, ultimately limiting viral propagation within macrophages. This discovery establishes CHROMR as an essential mediator of antiviral defense in the human innate immune system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Coen van Solingen, Yannick Cyr, Kaitlyn R Scacalossi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "CHROMR"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " regulates antiviral immunity in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2210321119"}], "href": "https://doi.org/10.1073/pnas.2210321119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36001732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36001732"}]}]}]}