{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM92A1 (also known as BARMR1) is a multifunctional BAR domain–containing protein with diverse roles in cellular organization, energy regulation, development, and cancer. In the context of ciliogenesis, FAM92A1 interacts with the coiled‐coil protein Chibby1 to recruit small vesicles that mediate ciliary vesicle formation and basal body docking—processes essential for both primary and multiciliated cell function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, FAM92A1 localizes to the matrix side of the mitochondrial inner membrane where it induces membrane curvature and maintains mitochondrial ultrastructure, a function crucial for optimal bioenergetics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Alternative splicing generates isoforms such as FAM92A1‐289, which have been implicated in tumorigenesis. Overexpression of these isoforms promotes cell proliferation, migration, and resistance to treatment by engaging signaling cascades (for example, the ERK pathway) and modulating the expression of oncogenic mediators—findings documented in renal, cervical, and glioblastoma models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, genetic variants in FAM92A1 have been linked to congenital limb malformations such as postaxial polydactyly, underscoring its contribution to developmental patterning."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Studies in developmental models further support an essential role for FAM92A1 homologs during embryogenesis, where perturbation of its expression leads to defects in ectoderm and mesoderm differentiation and subsequent developmental abnormalities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings illustrate that FAM92A1 is a critical organizer of membrane architecture—functioning in both the formation of cilia and mitochondria—and a modulator of proliferative and developmental processes. Its multifaceted activities position FAM92A1 as an important candidate for therapeutic targeting in ciliopathies, mitochondrial dysfunction, and cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng-Qian Li, Xingwang Chen, Cody Fisher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00160-16"}], "href": "https://doi.org/10.1128/MCB.00160-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27528616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27528616"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xu Zhi Ruan, Xin Rong Guo, Xuan Bin Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201806191"}], "href": "https://doi.org/10.1083/jcb.201806191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30404948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30404948"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zuoneng Wang, Carsten Mim "}, {"type": "b", "children": [{"type": "t", "text": "Optimizing purification of the peripheral membrane protein FAM92A1 fused to a modified spidroin tag."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Expr Purif (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pep.2021.105992"}], "href": "https://doi.org/10.1016/j.pep.2021.105992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34648955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34648955"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shufang Liang, Fengming Gong, Xinyu Zhao, et al. 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