{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CIBAR2, also known as FAM92B, encodes a protein predicted to harbor a lipid‐binding BAR domain that plays an important role in ciliogenesis. Studies have demonstrated that FAM92B interacts with the distal appendage/transition fiber protein Chibby1 (Cby1), thereby contributing to the recruitment of small vesicles and the remodeling of membranes required for proper basal body docking and ciliary vesicle formation in multiciliated cells (for instance, in the airways and brain ventricles)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n In genome‐wide association studies, FAM92B was initially predicted as a candidate gene associated with Crohn’s disease; however, while a signal was detected in some populations, further analyses in European cohorts did not confirm a robust association."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n More recently, network‐based analyses in Alzheimer’s disease risk prediction models have implicated FAM92B/CIBAR2 as a “dark gene” connected to immune and cellular signaling pathways, suggesting potential roles in neurodegenerative processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings support a model in which CIBAR2/FAM92B functions primarily in the regulation of ciliogenesis through its interaction with key ciliary proteins and membrane‐remodeling processes, while also serving as a putative risk factor in inflammatory and neurodegenerative diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng-Qian Li, Xingwang Chen, Cody Fisher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00160-16"}], "href": "https://doi.org/10.1128/MCB.00160-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27528616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27528616"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John D Rioux, Ramnik J Xavier, Kent D Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng2032"}], "href": "https://doi.org/10.1038/ng2032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17435756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17435756"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jürgen Glas, Julia Seiderer, Giulia Pasciuto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Gastroenterol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ajg.2008.65"}], "href": "https://doi.org/10.1038/ajg.2008.65"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19262523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19262523"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jessica Binder, Oleg Ursu, Cristian Bologa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-022-03068-7"}], "href": "https://doi.org/10.1038/s42003-022-03068-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35149761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35149761"}]}]}]}