CIRSR Gene

Name	corepressor of RBPJ and splicing regulator
Description	Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]
NCBI Gene ID	9541
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CIRSR has 1,372 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 20 datasets.

Click the + buttons to view associations for CIRSR from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CIRSR Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CIRSR gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CIRSR gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CIRSR gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CIRSR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CIRSR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	GTEx eQTL 2025	SNPs regulating expression of CIRSR gene from the GTEx eQTL 2025 dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of CIRSR gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of CIRSR gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	KEGG Pathways 2026	pathways involving CIRSR protein from the KEGG Pathways 2026 dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of CIRSR gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of CIRSR gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of CIRSR gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of CIRSR gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of CIRSR gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of CIRSR gene from the RummaGEO Gene Perturbation Signatures dataset.
	Sci-Plex Drug Perturbation Signatures	drug perturbations changing expression of CIRSR gene from the Sci-Plex Drug Perturbation Signatures dataset.
	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	drug perturbations changing expression of CIRSR gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of CIRSR protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of CIRSR protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with CIRSR protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.