CKS1B Gene

Name	CDC28 protein kinase regulatory subunit 1B
Description	CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CKS1B is a small, evolutionarily conserved cyclin‐dependent kinase subunit that plays a critical role in cell cycle regulation across a range of human cancers. As an essential cofactor of the SCF<sup>Skp2</sup> ubiquitin ligase complex, CKS1B facilitates the targeted ubiquitination and subsequent proteasomal degradation of cyclin‐dependent kinase inhibitors—most notably p27<sup>Kip1</sup> (and in some contexts p21)—thereby promoting the G1/S phase transition and robust cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its classic role in p27<sup>Kip1</sup> turnover, CKS1B may also activate alternative, p27‐independent pathways that enhance tumor cell growth, contribute to multidrug resistance, and help override intra‐S‐phase checkpoints under conditions of replication stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Clinically, overexpression of CKS1B has been observed in diverse malignancies—including multiple myeloma, melanoma, non‐small cell lung cancer, and colorectal carcinoma—and is strongly associated with decreased p27<sup>Kip1</sup> levels, enhanced cell cycle progression, and poor patient prognosis. These findings underscore its potential as both a prognostic marker and a therapeutic target in aggressive, high‐risk tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tarig Bashir, N Valerio Dorrello, Virginia Amador, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature02330"}], "href": "https://doi.org/10.1038/nature02330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15014502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15014502"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fenghuang Zhan, Simona Colla, Xiaosong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-07-038703"}], "href": "https://doi.org/10.1182/blood-2006-07-038703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17303695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17303695"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jessica Dal Col, Paola Zancai, Liliana Terrin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-103481"}], "href": "https://doi.org/10.1182/blood-2007-07-103481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18339899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18339899"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Naoki Inui, Kyoko Kitagawa, Seiichi Miwa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of Cks1 in human non-small cell lung carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00469-8"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00469-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12670508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12670508"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shojiro Kitajima, Yasusei Kudo, Ikuko Ogawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)63264-6"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "63264-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15579456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15579456"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "K V Bhatt, R Hu, L S Spofford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209861"}], "href": "https://doi.org/10.1038/sj.onc.1209861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16924241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16924241"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1102434108"}], "href": "https://doi.org/10.1073/pnas.1102434108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21697511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21697511"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ma'anit Shapira, Ofer Ben-Izhak, Bishara Bishara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.20172"}], "href": "https://doi.org/10.1002/cncr.20172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15073847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15073847"}]}]}]}
Synonyms	CKS1, PNAS-16, PNAS-18, CKSHS1
Proteins	CKS1_HUMAN
NCBI Gene ID	1163
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CKS1B has 8,641 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for CKS1B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CKS1B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CKS1B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CKS1B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CKS1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CKS1B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving CKS1B protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CKS1B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CKS1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CKS1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CKS1B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CKS1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CKS1B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CKS1B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CKS1B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CKS1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CKS1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CKS1B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CKS1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CKS1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CKS1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CKS1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CKS1B protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CKS1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CKS1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CKS1B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CKS1B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CKS1B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CKS1B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CKS1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CKS1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CKS1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CKS1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CKS1B protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CKS1B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CKS1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CKS1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CKS1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CKS1B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CKS1B gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CKS1B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CKS1B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.