Name | clathrin binding box of aftiphilin containing 1 |
Description | Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n This synthesized summary integrates findings from multiple studies examining diverse biological processes including early neurodegenerative changes (1), autoimmune susceptibility (2), molecular surface characteristics (3), and tumorigenic as well as immunomodulatory pathways (4,5). It is important to note that none of the referenced abstracts specifically describe or characterize the function of CLBA1. Collectively, these investigations underscore the complexity of genetic regulation in conditions ranging from Alzheimer’s disease and rheumatoid arthritis to cancer, yet they do not provide evidence of a role for CLBA1 in any of these contexts. Further research explicitly targeting CLBA1 will be necessary to elucidate its functional significance in cellular processes or disease mechanisms.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " \n (5)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jaeyoon Chung, Xulong Wang, Toru Maruyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alzheimers Dement (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jalz.2017.11.006"}], "href": "https://doi.org/10.1016/j.jalz.2017.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29274321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29274321"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei-Chiao Chen, Wen-Chang Wang, Yukinori Okada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "rs2841277 ("}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PLD4"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ") is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.19419"}], "href": "https://doi.org/10.18632/oncotarget.19419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28969061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28969061"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dario Braga, Fabrizia Grepioni, Lucia Maini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Making crystals with a purpose; a journey in crystal engineering at the University of Bologna."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUCrJ (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S2052252517005917"}], "href": "https://doi.org/10.1107/S2052252517005917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28875024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28875024"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanzhi Jiang, Xiaozeng Lin, Anil Kapoor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM84B promotes prostate tumorigenesis through a network alteration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ther Adv Med Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1758835919846372"}], "href": "https://doi.org/10.1177/1758835919846372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31205500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31205500"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yi Zhang, Xuebing Di, Guoji Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An immune-related signature that to improve prognosis prediction of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Cancer Res (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33948357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33948357"}]}]}]}
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NCBI Gene ID | 122616 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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CLBA1 has 955 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 13 datasets.
Click the + buttons to view associations for CLBA1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing CLBA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with CLBA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with CLBA1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CLBA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing CLBA1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of CLBA1 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CLBA1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of CLBA1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of CLBA1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CLBA1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CLBA1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of CLBA1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with CLBA1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |