{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies highlight the multifaceted role of the long non‑coding RNA CLDN10‑AS1 in cancer and vascular pathology. In lung adenocarcinoma, CLDN10‑AS1 was identified within a competing endogenous RNA (ceRNA) network and found to be significantly associated with patient prognosis. Functional analyses indicate that the RNAs in this network are enriched for roles in cell migration, transmembrane receptor function, and protein kinase activity, suggesting that CLDN10‑AS1 may influence key oncogenic processes in lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, integrative multi‑omics analyses revealed that CLDN10‑AS1 forms part of a copy number variation‐associated signature of long non‑coding RNAs that correlates with poor clinical outcomes, underscoring its potential as a prognostic biomarker in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although other studies of colorectal and rectal cancers have delineated lncRNA‑related ceRNA networks to decipher tumor pathogenesis and survival prediction"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the specific contribution of CLDN10‑AS1 appears to extend beyond a mere network component, suggesting an active role in modulating tumor behavior.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its oncological implications, CLDN10‑AS1 is markedly up‑regulated in human endothelial cells following oxidized low‑density lipoprotein stimulation. This pronounced up‑regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "points toward a potential involvement in the vascular responses underlying endothelial dysfunction and atherogenesis. Finally, while reviews on long non‑coding RNAs in angiogenesis and vascular diseases provide broader context on lncRNA functions in these processes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", the emerging data on CLDN10‑AS1 reinforce its relevance as a biomarker and functional regulator across multiple disease settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Donghui Jin, Yuxuan Song, Yuan Chen, et al. 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