{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CLEC4G, which encodes the liver and lymph node sinusoidal endothelial cell C‐type lectin (LSECtin), is a multifunctional receptor that primarily recognizes specific glycan structures in a Ca²⁺‐dependent manner. Originally described as being expressed on sinusoidal endothelial cells of the liver and lymph node, CLEC4G is also found on subsets of dendritic cells and macrophages, where its expression is regulated by lineage‐specific transcription factors such as PU.1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its carbohydrate‐recognition domain selectively binds ligands bearing N‐acetylglucosamine motifs, leading to rapid internalization of bound molecules."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Beyond serving as a pathogen attachment factor for viruses such as Ebola, SARS coronavirus, hepatitis C virus, and Japanese encephalitis virus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", CLEC4G also engages endogenous ligands such as CD44, thereby contributing to the regulation of lymphocyte adhesion and trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the liver, CLEC4G has been shown to modulate immune responses by inhibiting T‐cell activation and proliferation, which can lead to dampened antiviral immunity and delayed viral clearance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, its functional versatility extends to noninfectious pathological settings, as interactions on tumor‐associated macrophages enhance cancer cell stemness and promote metastasis in liver and colon cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Genetic studies also indicate that variations in the CLEC4G locus may influence host susceptibility to viral infections such as SARS‐CoV‑2, highlighting its potential role in interindividual differences in infection outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings underscore the dual role of CLEC4G as both a pathogen recognition receptor and an immunomodulatory molecule that can affect viral pathogenesis and tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Angeles Dominguez-Soto, Laura Aragoneses-Fenoll, Enrique Martin-Gayo, et al. 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