{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CLUAP1, also known as IFT38, is a highly conserved protein that plays a central role in ciliogenesis by functioning as a critical subunit of the intraflagellar transport (IFT) machinery. In several model systems, CLUAP1 has been shown to localize at the base and tip of the cilium where it regulates the IFT cycle, ensuring proper assembly and maintenance of this sensory organelle."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Biochemical and structural analyses have further established that CLUAP1 is an integral component of the IFT-B complex, participating in defined subcomplexes that facilitate the transport of ciliary cargo along the axoneme. Its direct interactions with other IFT proteins underpin its crucial role in regulating ciliary protein trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its established function in cilia, CLUAP1 has been implicated in non‐ciliary roles. For example, studies in colorectal cancer models have identified CLUAP1 as a nuclear protein with a coiled‐coil domain whose expression correlates with cell cycle progression and tumor cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, genetic association studies have provided preliminary evidence linking variations in CLUAP1 to the modulation of age of onset in Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementary genome‐editing studies have also revealed that CLUAP1 not only functions in ciliary assembly but may additionally influence cytoskeletal arrangements and intracellular transport processes, further expanding its functional repertoire. Evolutionary comparisons even suggest that CLUAP1 shares conserved domains with kinetochore proteins, hinting at a multifaceted role in maintaining cellular organization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies highlight CLUAP1 as an essential regulator of ciliary assembly and function with broader implications in developmental biology, neurodegeneration, and cancer, making it a promising candidate for further investigation in diverse pathological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanick Botilde, Satoko Yoshiba, Kyosuke Shinohara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2013.05.024"}], "href": "https://doi.org/10.1016/j.ydbio.2013.05.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23742838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23742838"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zachry T Soens, Yuanyuan Li, Li Zhao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12722"}], "href": "https://doi.org/10.1111/gtc.12722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31554018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31554018"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Meiko Takahashi, Yu-Min Lin, Yusuke Nakamura, et al. 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