{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The cannabinoid receptor‐2 (CB2; encoded by the CNR2 gene) is emerging as a key modulator across multiple biological systems. In the central nervous system, CB2 receptors expressed on neurons and glial cells regulate dopamine‐dependent reward pathways and can attenuate the locomotor‐stimulatory and reinforcing effects of drugs such as cocaine and nicotine, thereby influencing addiction‐related behaviors (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in several neurodegenerative and neuroinflammatory conditions – including amyotrophic lateral sclerosis, Alzheimer’s disease, traumatic brain injury, and disorders linked to aberrant axon guidance – CB2 activation has been shown to modulate inflammation and promote neuroprotection (e.g."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n CB2 receptors also have prominent immunomodulatory roles. They are expressed at high levels on immune cells and regulate various functions including cell migration, chemotaxis, and cytokine production. For example, CB2 activation contributes to the retention and mobilization of B cells within bone marrow and splenic marginal zones"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", modulates T‐cell and eosinophil responsiveness thereby limiting excessive inflammation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and induces B‐cell class switching toward IgE production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In addition, CB2‐mediated signaling in monocytes and macrophages – via distinct intracellular trafficking and coupling mechanisms"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "– affects inflammatory gene expression, cell migration, and apoptotic responses in settings as diverse as leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", liver fibrosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", and atherogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In peripheral metabolic tissues, CB2 receptors influence energy homeostasis and adipose tissue function. Their activation contributes to modulation of food intake and body weight regulation, and favorable shifts in adipocyte activity and lipid metabolism have been observed in obesity models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Furthermore, CB2 signaling in osteoblasts stimulates proliferation via MAPK pathways, implicating the receptor in bone formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ", and a shift toward CB2 expression has been documented in human heart tissue in chronic heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies have characterized CB2 as a protooncogene in certain myeloid leukemias"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ", where its ligand‐dependent signaling influences both cell migration and differentiation. Moreover, synthetic cannabinoids and their metabolites display high affinity at CB2 receptors with unique signaling profiles that might underlie differential therapeutic or toxicological effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Taken together, the collective evidence demonstrates that CNR2/CB2 receptors are multifunctional – orchestrating neurotransmission, immune cell trafficking, inflammatory responses, and metabolic as well as developmental processes. These diverse actions make CB2 a promising target for therapeutic interventions in neurodegeneration, addiction, inflammatory diseases, and metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "27"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zheng-Xiong Xi, Xiao-Qing Peng, Xia Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2874"}], "href": "https://doi.org/10.1038/nn.2874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21785434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21785434"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Aron H Lichtman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00213-013-3117-6"}], "href": "https://doi.org/10.1007/s00213-013-3117-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23652588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23652588"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jennifer L Shoemaker, Kathryn A Seely, Ronald L Reed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2006.04346.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2006.04346.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17241118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17241118"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anne-Caroline Schmöle, Ramona Lundt, Svenja Ternes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2014.09.019"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2014.09.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25443294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25443294"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ana Belen Lopez-Rodriguez, Estefania Acaz-Fonseca, Maria-Paz Viveros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0128782"}], "href": "https://doi.org/10.1371/journal.pone.0128782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26039099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26039099"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gabriel Duff, Anteneh Argaw, Bruno Cecyre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor CB2 modulates axon guidance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0070849"}], "href": "https://doi.org/10.1371/journal.pone.0070849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23951024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23951024"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "João P Pereira, Jinping An, Ying Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1710"}], "href": "https://doi.org/10.1038/ni.1710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19252491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19252491"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sreemanti Basu, Avijit Ray, Bonnie N Dittel "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1102195"}], "href": "https://doi.org/10.4049/jimmunol.1102195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22048769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22048769"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sharmistha Ghosh, Anju Preet, Jerome E Groopman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2006.01.005"}], "href": "https://doi.org/10.1016/j.molimm.2006.01.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16503355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16503355"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "R B Frei, P Luschnig, G P Parzmair, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/all.12858"}], "href": "https://doi.org/10.1111/all.12858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26850094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26850094"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Marisela Agudelo, Cathy Newton, Ray Widen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmune Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11481-007-9088-9"}], "href": "https://doi.org/10.1007/s11481-007-9088-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18247126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18247126"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Natasha L Grimsey, Catherine E Goodfellow, Mike Dragunow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2011.05.010"}], "href": "https://doi.org/10.1016/j.bbamcr.2011.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21640764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21640764"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Robert J McKallip, Wentao Jia, Jerome Schlomer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.106.023937"}], "href": "https://doi.org/10.1124/mol.106.023937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16754784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16754784"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Adrien Guillot, Nabila Hamdaoui, Alexandra Bizy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26598"}], "href": "https://doi.org/10.1002/hep.26598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23813495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23813495"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Timothé Denaës, Jasper Lodder, Marie-Noële Chobert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep28806"}], "href": "https://doi.org/10.1038/srep28806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27346657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27346657"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Courtney D Netherland, Theresa G Pickle, Alicia Bales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2010.07.060"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2010.07.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20846652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20846652"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Slava Rom, Viviana Zuluaga-Ramirez, Holly Dykstra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2013.07.033"}], "href": "https://doi.org/10.1016/j.ajpath.2013.07.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24055259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24055259"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "A N A Verty, A Stefanidis, A J McAinch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0140592"}], "href": "https://doi.org/10.1371/journal.pone.0140592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26588700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26588700"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Francesca Rossi, Giulia Bellini, Livio Luongo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2015-4381"}], "href": "https://doi.org/10.1210/jc.2015-4381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27294325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27294325"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Orr Ofek, Malka Attar-Namdar, Vardit Kram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.228"}], "href": "https://doi.org/10.1002/jbmr.228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20803555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20803555"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Florian Weis, Andres Beiras-Fernandez, Ralf Sodian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2009.10.025"}], "href": "https://doi.org/10.1016/j.yjmcc.2009.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19931541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19931541"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Meritxell Alberich Jordà, Sandra E Verbakel, Peter J M Valk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.8.2786"}], "href": "https://doi.org/10.1182/blood.v99.8.2786"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11929767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11929767"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Maheswari Rajasekaran, Lisa K Brents, Lirit N Franks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Appl Pharmacol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.taap.2013.03.012"}], "href": "https://doi.org/10.1016/j.taap.2013.03.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23537664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23537664"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Slava Rom, Yuri Persidsky "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmune Pharmacol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11481-013-9445-9"}], "href": "https://doi.org/10.1007/s11481-013-9445-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23471521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23471521"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Sreemanti Basu, Bonnie N Dittel "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12026-011-8210-5"}], "href": "https://doi.org/10.1007/s12026-011-8210-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21626285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21626285"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "H Ishiguro, S Iwasaki, L Teasenfitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.tpj.6500431"}], "href": "https://doi.org/10.1038/sj.tpj.6500431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17189959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17189959"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Huan Gui, Xia Liu, Zhi-Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rheumatology (Oxford) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/rheumatology/ket447"}], "href": "https://doi.org/10.1093/rheumatology/ket447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24440992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24440992"}]}]}]}