{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have increasingly revealed that long noncoding RNAs (lncRNAs) contribute significantly to cancer biology through mechanisms such as microRNA sponging in competing endogenous RNA (ceRNA) networks. In muscle-invasive bladder cancer, comprehensive transcriptomic analyses identified a panel of dysregulated lncRNAs that participate in ceRNA networks and serve as candidate prognostic biomarkers and therapeutic targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although this study did not single out CNTFR-AS1, the work emphasizes the critical role of lncRNA-mediated regulation in tumorigenesis. In a separate investigation examining breast cancer subtypes, CNTFR-AS1 was among several lncRNAs whose high expression levels were associated with poorer overall survival in triple-negative breast cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings suggest that CNTFR-AS1 may act as an oncogenic regulator likely involved in miRNA-mediated gene regulation, thereby representing a potential prognostic biomarker and therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hanbo Wang, Leilei Niu, Shaobo Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA network in muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13363"}], "href": "https://doi.org/10.18632/oncotarget.13363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27863388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27863388"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Xiao Li, Li-Juan Wang, Jie Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Long Noncoding RNAs as Predictors of Survival in Triple-Negative Breast Cancer Based on Network Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8970340"}], "href": "https://doi.org/10.1155/2020/8970340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32190687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32190687"}]}]}]}