{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n COL18A1‐AS1 is a long noncoding RNA that has emerged as an important component within competing endogenous RNA (ceRNA) networks in several cancer types, including clear cell renal cell carcinoma (ccRCC) and cholangiocarcinoma. In these studies, dysregulation of COL18A1‐AS1 has been associated with patient prognosis and tumor progression. Its expression appears to modulate key cellular pathways—likely through sponging microRNAs and thereby influencing the expression of downstream mRNA targets—which may affect processes such as extracellular matrix interactions and cytokine signaling. Moreover, COL18A1‐AS1 has been identified as part of multi‐lncRNA prognostic signatures, suggesting that its level of expression could serve as a potential predictive biomarker for overall survival and tumor aggressiveness. Together, these findings implicate COL18A1‐AS1 as a functional regulator in tumorigenesis and indicate its utility in refining prognostic models in malignancies like ccRCC and cholangiocarcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenjun Lu, Hengchen Liu, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/8504441"}], "href": "https://doi.org/10.1155/2022/8504441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35529267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35529267"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheng Zhang, Chunlin Ge "}, {"type": "b", "children": [{"type": "t", "text": "A Simple Competing Endogenous RNA Network Identifies Novel mRNA, miRNA, and lncRNA Markers in Human Cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/3526407"}], "href": "https://doi.org/10.1155/2019/3526407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31019967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31019967"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wanting Hou, Qiulin Tang, Feng Bi "}, {"type": "b", "children": [{"type": "t", "text": "[Comprehensive analysis of the aberrantly expressed profiles of lncRNAs, miRNAs and the regulation network of the associated ceRNAs in clear cell renal cell carcinoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7507/1001-5515.201801057"}], "href": "https://doi.org/10.7507/1001-5515.201801057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31016944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31016944"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang Wang, Kai Bin Hu, You Qian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of aberrantly expressed profiles of lncRNAs, miRNAs and mRNAs with associated ceRNA network in cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181684"}], "href": "https://doi.org/10.3233/CBM-181684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30452401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30452401"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiawu Wang, Chengyao Zhang, Weiyang He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and comprehensive analysis of dysregulated long non-coding RNA-associated competing endogenous RNA network in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27557"}], "href": "https://doi.org/10.1002/jcb.27557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30278113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30278113"}]}]}]}