{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the long non‐coding RNA COL4A2‐AS1 in tumor progression and prognosis across different cancer types. In colorectal cancer, COL4A2‐AS1 has been shown to influence key cellular processes including proliferation, colony formation, and apoptosis, with in vitro assays and in vivo xenograft models demonstrating its role in promoting tumorigenesis and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in breast cancer, integrative bioinformatics analysis within a competing endogenous RNA (ceRNA) network identified COL4A2‐AS1 as one of several long non‐coding RNAs whose expression is closely correlated with patient prognosis, highlighting its potential as a novel therapeutic target and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zijun Yu, Yeming Wang, Jianwu Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1969833"}], "href": "https://doi.org/10.1080/21655979.2021.1969833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34477476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34477476"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Yao, Tingting Zhang, Lingyu Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of co-expression and ceRNA network identifies five lncRNAs as prognostic markers for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14721"}], "href": "https://doi.org/10.1111/jcmm.14721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31613058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31613058"}]}]}]}