{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In recent work, COL4A2‑AS2 has been identified as one of several long non‑coding RNAs that are differentially expressed in the subcutaneous adipose tissue of women with obesity (1). Although details about COL4A2‑AS2’s specific mechanisms were not fully delineated, its dysregulation during adipogenesis was highlighted through both in silico dissection and in vitro validation. In particular, COL4A2‑AS2, along with other lncRNAs, exhibits dynamic expression changes as adipose‑derived stem cells differentiate into adipocytes, suggesting that it may be intertwined in the regulatory network that controls adipocyte differentiation. Furthermore, its expression appears to be modulated by key adipogenic transcription factors such as C/EBPs and PPARγ, indicating a potential role in the transcriptional regulation of adipogenesis and, by extension, obesity‑related pathology (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Federica Rey, Letizia Messa, Cecilia Pandini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional characterization of subcutaneous adipose tissue in obesity affected women highlights metabolic dysfunction and implications for lncRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.09.014"}], "href": "https://doi.org/10.1016/j.ygeno.2021.09.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34555498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34555498"}]}]}]}