{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have identified a long non‐coding RNA, commonly referred to as COPG2IT1 (also known as the antisense transcript CIT1), which is located within an intronic region of the COPG2 gene. In mouse, an untranslated transcript named Mit1/Lb9 resides within intron 20 of Copg2 and is maternally imprinted, whereas in humans the COPG2IT1 transcript shows paternal‐specific expression in fetal tissues even though the adjacent, protein‐coding COPG2 is expressed biallelically."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Along with MEST and MESTIT1, COPG2IT1 forms part of an imprinted gene cluster at human chromosome 7q32"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", suggesting that these transcripts collectively contribute to the allele‐specific regulation of gene expression within this region. Further analysis has shown that while neighboring genes like TSGA14 display biallelic expression, the imprinting of COPG2IT1 appears to be a unique, conserved feature that may serve a cis‐regulatory role, potentially through mechanisms such as transcriptional interference or modulation of chromatin structure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings indicate that COPG2IT1 is not merely a by‐product of transcription but rather a functional non‐coding RNA that may influence the local epigenetic landscape and transcriptional output of imprinted genes during development.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y J Lee, C W Park, Y Hahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(00)01461-7"}], "href": "https://doi.org/10.1016/s0014-5793(00"}, {"type": "t", "text": "01461-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10788617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10788617"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kazuhiko Nakabayashi, Louise Bentley, Megan P Hitchins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/11.15.1743"}], "href": "https://doi.org/10.1093/hmg/11.15.1743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12095916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12095916"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takahiro Yamada, Tomohiko Kayashima, Kentaro Yamasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The gene TSGA14, adjacent to the imprinted gene MEST, escapes genomic imprinting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0378-1119(02)00428-6"}], "href": "https://doi.org/10.1016/s0378-1119(02"}, {"type": "t", "text": "00428-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12034494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12034494"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "K Yamasaki, S Hayashida, K Miura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/geno.2000.6265"}], "href": "https://doi.org/10.1006/geno.2000.6265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10995575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10995575"}]}]}]}