COPS7A Gene

HGNC Family	COP9 signalosome (COPS)
Name	COP9 signalosome subunit 7A
Description	This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n COPS7A, a critical subunit of the COP9 signalosome complex, plays an important role in regulating protein stability and signal transduction through its participation in ubiquitin‐dependent pathways. Several studies have shown that COPS7A interacts with a range of regulatory proteins—including protein kinase CK2, the translation-associated factor Int‐6, the transcription modulators Id3 and PMF‑1—to help mediate phosphorylation events and modulate protein degradation via cullin‐RING ubiquitin ligases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, functional dissection of COP9 signalosome variants suggests that CSN7A and its paralog CSN7B have overlapping functions in supporting deneddylation processes that maintain proper activity of ubiquitin ligases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the context of cancer, altered regulation of COPS7A has been implicated in controlling cell proliferation and metastasis; for example, non-coding RNAs such as LOC339524 and KRT19P3 modulate COPS7A expression, which in turn affects the deubiquitination of IκBα via USP15 and thereby dampens NF-κB signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings highlight COPS7A as a pivotal mediator linking the COP9 signalosome to diverse cellular processes that regulate protein turnover and signal transduction, with significant implications for cell homeostasis and disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stefan Uhle, Ohad Medalia, Richard Waldron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg127"}], "href": "https://doi.org/10.1093/emboj/cdg127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12628923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12628923"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael Hans Olma, Marcia Roy, Thierry Le Bihan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.043539"}], "href": "https://doi.org/10.1242/jcs.043539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19295130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19295130"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karine Hoareau Alves, Valérie Bochard, Stéphane Réty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)03147-2"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "03147-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12220626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12220626"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Matthias Berse, Mangkey Bounpheng, Xiaohua Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2004.08.043"}], "href": "https://doi.org/10.1016/j.jmb.2004.08.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15451666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15451666"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yanlin Wang, Wendy Devereux, Tracy M Stewart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20020211"}], "href": "https://doi.org/10.1042/BJ20020211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12020345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12020345"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jing Wang, Dawadschargal Dubiel, Yanmeng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.108662"}], "href": "https://doi.org/10.1016/j.celrep.2020.108662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33503427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33503427"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xuan He, He Xiao, Rui Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA LOC339524 inhibits the proliferation of bladder cancer cells by targeting the miR-875-5p/COPS7A signaling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2021.10636"}], "href": "https://doi.org/10.3892/etm.2021.10636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34584547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34584547"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jie Zheng, Hui Zhang, Ranran Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA KRT19P3 suppresses proliferation and metastasis through COPS7A-mediated NF-κB pathway in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-0934-z"}], "href": "https://doi.org/10.1038/s41388-019-0934-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409899"}]}]}]}
Synonyms	CSN7, CSN7A, SGN7A
Proteins	CSN7A_HUMAN
NCBI Gene ID	50813
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

COPS7A has 7,122 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for COPS7A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

COPS7A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of COPS7A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of COPS7A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of COPS7A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of COPS7A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of COPS7A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of COPS7A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of COPS7A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of COPS7A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of COPS7A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of COPS7A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of COPS7A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with COPS7A protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of COPS7A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of COPS7A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of COPS7A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing COPS7A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of COPS7A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing COPS7A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing COPS7A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with COPS7A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with COPS7A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing COPS7A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of COPS7A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with COPS7A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with COPS7A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of COPS7A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by COPS7A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with COPS7A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with COPS7A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with COPS7A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with COPS7A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at COPS7A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of COPS7A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of COPS7A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing COPS7A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of COPS7A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing COPS7A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of COPS7A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of COPS7A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of COPS7A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.