{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n COX10‐AS1, an antisense long noncoding RNA, plays multifaceted oncogenic roles in various cancers by modulating microRNA‐mediated regulatory networks. In non–small cell lung cancer, COX10‐AS1 acts as a competing endogenous RNA that sequesters miR‑142‑5p, thereby restoring PAICS expression to promote glycolysis, enhance cell proliferation, and inhibit apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioma, elevated COX10‑AS1 levels facilitate tumor progression by sponging miR‑641 to upregulate the transcription factor E2F6, which in turn promotes proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In glioblastoma, COX10‑AS1 similarly functions as an endogenous sponge for miR‑361‑5p, leading to increased ACTG1 expression that supports tumor cell proliferation while suppressing apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, in triple‑negative breast cancer, lower expression levels of COX10‑AS1 are associated with poorer patient survival, and in oral squamous cell carcinoma, its differential expression underscores a potential role in carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these studies reveal that COX10‑AS1 contributes to tumorigenesis by modulating key cellular processes through distinct miRNA target axes, making it a promising prognostic biomarker and therapeutic target across multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinyu Tang, YiHe Wu, Jie Yang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "COX10-AS1 Facilitates Cell Proliferation and Inhibits Cell Apoptosis in Glioblastoma Cells at Post-Transcription Level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11064-020-03081-4"}], "href": "https://doi.org/10.1007/s11064-020-03081-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32770454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32770454"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiao-Xiao Li, Li-Juan Wang, Jie Hou, et al. 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