{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CRHR1‐IT1 is an intronic noncoding transcript produced from the CRHR1 genomic locus, which is located in the complex 17q21.31 region. Although none of the provided abstracts investigate CRHR1‐IT1 directly, several studies of this region shed light on its likely regulatory role. The 17q21.31 interval is notable for an inversion polymorphism and recurrent microdeletions that affect multiple genes (for example, MAPT, CRHR1, and KANSL1) known to influence neurological development and neurodegeneration. In these studies, genomic structural variation and transcriptional regulatory analyses in subjects with neurodegenerative disorders and related traits highlight that noncoding elements within this region, including CRHR1‐IT1, may serve as modulators of gene expression and chromatin organization, thereby influencing disease susceptibility."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Specifically, the disruption or altered expression of regulatory transcripts in the 17q21.31 region has been implicated in disorders such as Parkinson’s disease, Alzheimer’s disease, and neurodevelopmental syndromes. Given its genomic context, CRHR1‐IT1 is postulated to contribute to the fine‐tuning of stress response and neuronal function through cis‐regulatory mechanisms, in concert with protein‐coding genes that are functionally linked to neuronal integrity and synaptic plasticity. These insights come from integrative studies that document the clinical impact of structural variants and gene expression changes in this locus (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, although direct functional studies of CRHR1‐IT1 remain to be performed, current genomic and transcriptomic data support a role for this noncoding RNA in modulating local gene expression and chromatin architecture within an evolutionarily dynamic region associated with several neuropsychiatric and neurodegenerative conditions. Future investigations that specifically target CRHR1‐IT1 will be necessary to fully clarify its biological functions and its potential contribution to disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "D A Koolen, A J Sharp, J A Hurst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and molecular delineation of the 17q21.31 microdeletion syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2008.058701"}], "href": "https://doi.org/10.1136/jmg.2008.058701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18628315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18628315"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer Permuth-Wey, Kate Lawrenson, Howard C Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2613"}], "href": "https://doi.org/10.1038/ncomms2613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23535648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23535648"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "G Jun, C A Ibrahim-Verbaas, M Vronskaya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel Alzheimer disease locus located near the gene encoding tau protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2015.23"}], "href": "https://doi.org/10.1038/mp.2015.23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25778476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25778476"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Frederik Sündermann, Maria-Pilar Fernandez, Reginald O Morgan "}, {"type": "b", "children": [{"type": "t", "text": "An evolutionary roadmap to the microtubule-associated protein MAP Tau."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2590-9"}], "href": "https://doi.org/10.1186/s12864-016-2590-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27030133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27030133"}]}]}]}