CSF3R Gene

HGNC Family	Fibronectin type III domain containing, CD molecules (CD)
Name	colony stimulating factor 3 receptor (granulocyte)
Description	The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The granulocyte colony‐stimulating factor receptor (CSF3R) is a pivotal cytokine receptor that mediates the effects of G‐CSF in regulating granulopoiesis, neutrophil differentiation, mobilization, and function. CSF3R signaling is essential not only for maintaining basal neutrophil levels and directing the expansion of myeloid progenitors from primitive hematopoietic stem cells but also for orchestrating emergency granulopoiesis and rapid neutrophil trafficking during inflammatory and infectious stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Activation of CSF3R triggers downstream pathways—including JAK–STAT, SRC family kinases, and MAP kinase cascades—that are crucial for survival, chemotactic responses, and actin reorganization in neutrophils."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of hematologic disorders, both activating missense mutations (e.g., CSF3R T618I) and truncation mutations affecting the cytoplasmic domain have been identified in patients with chronic neutrophilic leukemia and severe congenital neutropenia, underscoring CSF3R’s critical role in myeloid transformation and its utility as a diagnostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n The activity of CSF3R is further modulated by extracellular factors and intracellular regulators. Proteolytic processing by dipeptidylpeptidase 4 (DPP4) can attenuate the activity of G‐CSF, thereby influencing receptor signaling, while microRNAs (through targeting of effector molecules such as SQSTM1) have been shown to enhance CSF3R‐mediated MAP kinase signaling and promote progenitor cell expansion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, genetic variation in CSF3R, along with receptor cross‐talk with additional signaling systems, may fine‐tune responsiveness to G‐CSF and contribute to the phenotypic diversity observed in myeloproliferative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael K Richards, Fulu Liu, Hiromi Iwasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-02-0593"}], "href": "https://doi.org/10.1182/blood-2003-02-0593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12893769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12893769"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Craig L Semerad, Fulu Liu, Alyssa D Gregory, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1074-7613(02)00424-7"}], "href": "https://doi.org/10.1016/s1074-7613(02"}, {"type": "t", "text": "00424-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12387736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12387736"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Antje M Wengner, Simon C Pitchford, Rebecca C Furze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-099648"}], "href": "https://doi.org/10.1182/blood-2007-07-099648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17928531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17928531"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Athanasia D Panopoulos, Ling Zhang, Jonathan W Snow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-02-003012"}], "href": "https://doi.org/10.1182/blood-2006-02-003012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16888100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16888100"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Meritxell Alberich Jordà, Sandra E Verbakel, Peter J M Valk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.8.2786"}], "href": "https://doi.org/10.1182/blood.v99.8.2786"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11929767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11929767"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Julia E Maxson, Jason Gotlib, Daniel A Pollyea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa1214514"}], "href": "https://doi.org/10.1056/NEJMoa1214514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23656643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23656643"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "A Pardanani, T L Lasho, R R Laborde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2013.122"}], "href": "https://doi.org/10.1038/leu.2013.122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23604229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23604229"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hal E Broxmeyer, Jonathan Hoggatt, Heather A O'Leary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2991"}], "href": "https://doi.org/10.1038/nm.2991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23160239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23160239"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Annemarie Meenhuis, Peter A van Veelen, Hans de Looper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-02-336487"}], "href": "https://doi.org/10.1182/blood-2011-02-336487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21628417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21628417"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Animesh Pardanani, Brooke L Fridley, Terra L Lasho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-06-095703"}], "href": "https://doi.org/10.1182/blood-2007-06-095703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18006699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18006699"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jo L Eyles, Michael J Hickey, M Ursula Norman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-02-139535"}], "href": "https://doi.org/10.1182/blood-2008-02-139535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18824600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18824600"}]}]}]}
Synonyms	SCN7, CD114, GCSFR
Proteins	CSF3R_HUMAN
NCBI Gene ID	1441
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CSF3R has 5,964 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for CSF3R from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CSF3R Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CSF3R gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSF3R gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSF3R gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CSF3R gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CSF3R gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CSF3R gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSF3R gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CSF3R gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CSF3R gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CSF3R gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CSF3R gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CSF3R gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CSF3R gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CSF3R gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CSF3R gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSF3R gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CSF3R gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CSF3R gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with CSF3R gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CSF3R gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CSF3R gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CSF3R protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CSF3R protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CSF3R protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CSF3R protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CSF3R gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CSF3R gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CSF3R gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CSF3R gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CSF3R gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CSF3R gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CSF3R gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CSF3R gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CSF3R gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CSF3R gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CSF3R gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CSF3R protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CSF3R gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSF3R gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CSF3R gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.