{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have increasingly implicated the long non‐coding RNA CSMD2‑AS1 as a potential oncogenic factor with prognostic significance in cancer. In triple‑negative breast cancer, for example, high expression levels of CSMD2‑AS1 were identified as part of a panel of dysregulated lncRNAs associated with lower overall survival, suggesting that CSMD2‑AS1 may contribute to tumor progression and represent a novel biomarker for poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In broader analyses of hematological malignancies, including diffuse large B‑cell lymphoma and other B‑cell tumors, deregulated lncRNAs have been shown to modulate cancer‐related pathways, immune signaling, and gene regulatory networks, although the specific role of CSMD2‑AS1 in these processes has yet to be defined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings indicate that CSMD2‑AS1 may serve as a critical molecular player whose aberrant expression is linked to adverse clinical outcomes across different cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Xiao Li, Li-Juan Wang, Jie Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Long Noncoding RNAs as Predictors of Survival in Triple-Negative Breast Cancer Based on Network Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8970340"}], "href": "https://doi.org/10.1155/2020/8970340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32190687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32190687"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Sun, Liang Cheng, Hongbo Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potential panel of six-long non-coding RNA signature to improve survival prediction of diffuse large-B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep27842"}], "href": "https://doi.org/10.1038/srep27842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27292966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27292966"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lucia Nobili, Domenica Ronchetti, Elisa Taiana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs in B-cell malignancies: a comprehensive overview."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.17303"}], "href": "https://doi.org/10.18632/oncotarget.17303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28947998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28947998"}]}]}]}