{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCurrent advances in synaptic biology have revealed a highly dynamic interplay among presynaptic and postsynaptic adhesion molecules that orchestrate synapse formation, maturation, and plasticity. Numerous studies have detailed how key proteins such as neurexins, neuroligins, cerebellin family members, and other modulators regulate trans‐synaptic signaling and receptor targeting through mechanisms including alternative splicing, proteolytic processing, and regulated membrane trafficking."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations have dissected the molecular codes and regulatory circuits—such as activity‐dependent alternative splicing, posttranslational modifications, and precise intracellular transport—that fine‐tune synaptic properties and ensure proper neurotransmission. These studies, employing genetic models, super‐resolution imaging, and biochemical analyses, have advanced our understanding of how synaptic organizers modulate excitatory and inhibitory balance and influence behaviors relevant to neuropsychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite the rich mechanistic insights provided by these studies on synaptic organizers, none of the available abstracts address or even reference CSPG4P1Y. In contrast to the well‐characterized roles of proteins like neurexins, neuroligins, Cbln1, and associated partners in synaptic adhesion, receptor regulation, and network connectivity"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "32"}]}, {"type": "t", "text": ", the functional role of CSPG4P1Y in neural wiring, synaptic assembly, or plasticity has not been elucidated. Its absence from these investigations leaves open the possibility that CSPG4P1Y may either be functionally silent or have a yet‐to‐be‐discovered, subtle modulatory role in the synaptic processes governed by these established molecular networks.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Davide Comoletti, Robyn Flynn, Lori L Jennings, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M306803200"}], "href": "https://doi.org/10.1074/jbc.M306803200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14522992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14522992"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gunnar Kattenstroth, Evangelia Tantalaki, Thomas C Südhof, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0308626100"}], "href": "https://doi.org/10.1073/pnas.0308626100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14983056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14983056"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Richard Fairless, Henriette Masius, Astrid Rohlmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5294-07.2008"}], "href": "https://doi.org/10.1523/JNEUROSCI.5294-07.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19036990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19036990"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mark R Etherton, Cory A Blaiss, Craig M Powell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0910297106"}], "href": "https://doi.org/10.1073/pnas.0910297106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19822762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19822762"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alessia Bottos, Erika Destro, Alberto Rissone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0809510106"}], "href": "https://doi.org/10.1073/pnas.0809510106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19926856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19926856"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Takeshi Uemura, Sung-Jin Lee, Misato Yasumura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2010.04.035"}], "href": "https://doi.org/10.1016/j.cell.2010.04.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20537373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20537373"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Fu, Z Josh Huang "}, {"type": "b", "children": [{"type": "t", "text": "Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1011233108"}], "href": "https://doi.org/10.1073/pnas.1011233108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21149722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21149722"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Keiko Matsuda, Michisuke Yuzaki "}, {"type": "b", "children": [{"type": "t", "text": "Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2011.07638.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2011.07638.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21410790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21410790"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Carlos A Saura, Emilia Servián-Morilla, Francisco G Scholl "}, {"type": "b", "children": [{"type": "t", "text": "Presenilin/γ-secretase regulates neurexin processing at synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0019430"}], "href": "https://doi.org/10.1371/journal.pone.0019430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21559374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21559374"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Takatoshi Iijima, Karen Wu, Harald Witte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.11.028"}], "href": "https://doi.org/10.1016/j.cell.2011.11.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22196734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22196734"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Merrie Mosedale, Sonya Egodage, Rei C Calma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurexin-1α contributes to insulin-containing secretory granule docking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.299081"}], "href": "https://doi.org/10.1074/jbc.M111.299081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22235116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22235116"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marijke C Laarakker, Niels R Reinders, Hilgo Bruining, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-dependent novelty response in neurexin-1α mutant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0031503"}], "href": "https://doi.org/10.1371/journal.pone.0031503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22348092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22348092"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "K Mozhui, X Wang, J Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2011.24"}], "href": "https://doi.org/10.1038/tp.2011.24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22832527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22832527"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Aya Ito-Ishida, Taisuke Miyazaki, Eriko Miura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2012.07.027"}], "href": "https://doi.org/10.1016/j.neuron.2012.07.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23141067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23141067"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hannah Mary Grayton, Markus Missler, David Andrew Collier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0067114"}], "href": "https://doi.org/10.1371/journal.pone.0067114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23840597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23840597"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Luis G Rabaneda, Estefanía Robles-Lanuza, José Luis Nieto-González, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurexin dysfunction in adult neurons results in autistic-like behavior in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.06.022"}], "href": "https://doi.org/10.1016/j.celrep.2014.06.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25017069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25017069"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Won Hee Jang, Sun Hee Choi, Joo Young Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal cell-surface protein neurexin 1 interaction with multi-PDZ domain protein MUPP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2014.890031"}], "href": "https://doi.org/10.1080/09168451.2014.890031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25036961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25036961"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Christian Neupert, Romy Schneider, Oliver Klatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4041-14.2015"}], "href": "https://doi.org/10.1523/JNEUROSCI.4041-14.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26446217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26446217"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "James Dachtler, Jose L Ivorra, Tessa E Rowland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1037/bne0000108"}], "href": "https://doi.org/10.1037/bne0000108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26595880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26595880"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sandeep K Singh, Jeff A Stogsdill, Nisha S Pulimood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.11.034"}], "href": "https://doi.org/10.1016/j.cell.2015.11.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26771491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26771491"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Τao Zhu, Chen Liang, Dongdong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26597"}], "href": "https://doi.org/10.1038/srep26597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27229316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27229316"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Fredrik H Sterky, Justin H Trotter, Sung-Jin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1621321114"}], "href": "https://doi.org/10.1073/pnas.1621321114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28154140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28154140"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-06333-8"}], "href": "https://doi.org/10.1038/s41467-018-06333-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30262834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30262834"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jinye Dai, Jason Aoto, Thomas C Südhof "}, {"type": "b", "children": [{"type": "t", "text": "Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2019.03.032"}], "href": "https://doi.org/10.1016/j.neuron.2019.03.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31005376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31005376"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Justin H Trotter, Junjie Hao, Stephan Maxeiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201812076"}], "href": "https://doi.org/10.1083/jcb.201812076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31262725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31262725"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Luís F Ribeiro, Ben Verpoort, Julie Nys, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.3000466"}], "href": "https://doi.org/10.1371/journal.pbio.3000466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31658245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31658245"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Emily C Armstrong, Angela Caruso, Michela Servadio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: Social and communication deficits in mice with Neurexin 1α deletion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gbb.12630"}], "href": "https://doi.org/10.1111/gbb.12630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31823470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31823470"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Reiko T Roppongi, Shreya H Dhume, Nirmala Padmanabhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2020.01.003"}], "href": "https://doi.org/10.1016/j.neuron.2020.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31995730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31995730"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Elisa Marchese, Mariagrazia Valentini, Gabriele Di Sante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2020.113497"}], "href": "https://doi.org/10.1016/j.expneurol.2020.113497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33058888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33058888"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.59545"}], "href": "https://doi.org/10.7554/eLife.59545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33355091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33355091"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Bing Xu, Yugong Ho, Maria Fasolino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1010659"}], "href": "https://doi.org/10.1371/journal.pgen.1010659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36848371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36848371"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Hong Lu, Long Zuo, Kyle M Roddick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2023.112714"}], "href": "https://doi.org/10.1016/j.celrep.2023.112714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37384525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37384525"}]}]}]}