{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CSTPP1 (also known as C11ORF49) is a novel regulator of the tubulin polyglutamylase complex (TPGC) that plays a critical role in coordinating cytoskeletal organization, nuclear morphology, and the disassembly of primary cilia (as described in."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistically, CSTPP1 is essential for the proper assembly and stability of the TPGC. By modulating the levels of long-chain polyglutamylation on microtubules, CSTPP1 balances the interaction of microtubule-associated proteins and actin nucleators. When CSTPP1 function is compromised, this balance is disturbed, leading to aberrant microtubule assembly that can penetrate the nucleus and cause defects in nuclear shape. Moreover, disruption of CSTPP1 affects the organization of cytoplasmic actin and interferes with the YAP/TAZ signaling pathway, ultimately impeding efficient cilium disassembly and triggering developmental defects in vivo. Overall, these findings underscore the role of CSTPP1 as a key molecular nexus linking microtubule post-translational modifications with nuclear architecture and ciliogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Wang, Sharad C Paudyal, Yuchen Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41422-021-00584-9"}], "href": "https://doi.org/10.1038/s41422-021-00584-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34782749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34782749"}]}]}]}