{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CT47A4 is a member of the cancer/testis antigen family, a group of genes that under normal conditions are expressed solely in germ cells but become aberrantly reactivated in various cancers. Its expression in malignant tissues is associated with an immunogenic tumor microenvironment, as illustrated by studies in breast lesions where CT antigens are notably upregulated in estrogen receptor–negative and HER2‐positive ductal carcinomas in situ, suggesting potential value as immunotherapy targets (1). Equally, in prostate cancer, cancer/testis antigens including members analogous to CT47A4 have been identified through high‐throughput antigen microarray screenings, implying a role in both the diagnostics and therapeutic stratification of aggressive tumors (2). Moreover, large-scale transcript cataloguing has expanded our understanding of the complexity and diversity of gene expression, with CT47A4 likely represented among the novel transcripts that contribute to the overall transcriptional “noise” yet may hold biological and clinical significance (3). Finally, integrating genomic profiles with clinical outcomes via machine learning approaches has underscored the potential of biomarkers like CT47A4 to aid in predicting patient survivability and refining personalized treatment regimens in cancers such as breast carcinoma (4)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Otavia L Caballero, Sami Shousha, Qi Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncoscience (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncoscience.4"}], "href": "https://doi.org/10.18632/oncoscience.4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25593980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25593980"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Henry A Adeola, Muneerah Smith, Lisa Kaestner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7359"}], "href": "https://doi.org/10.18632/oncotarget.7359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26885621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26885621"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mihaela Pertea, Alaina Shumate, Geo Pertea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13059-018-1590-2"}], "href": "https://doi.org/10.1186/s13059-018-1590-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30486838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30486838"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ashraf Abou Tabl, Abedalrhman Alkhateeb, Waguih ElMaraghy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Machine Learning Approach for Identifying Gene Biomarkers Guiding the Treatment of Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00256"}], "href": "https://doi.org/10.3389/fgene.2019.00256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30972106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30972106"}]}]}]}