CTCF Gene

HGNC Family	Zinc fingers
Name	CCCTC-binding factor (zinc finger protein)
Description	This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CTCF is a highly conserved zinc finger DNA‐binding protein that plays a central role in organizing the three‐dimensional genome and regulating gene expression. It functions as an insulator and boundary element by establishing topologically associating domains (TADs) and restricting inappropriate enhancer–promoter interactions at key loci (for example, at H19/IGF2 ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "]). In addition, CTCF collaborates with the cohesin complex to mediate long‐range chromatin looping, with its binding polarity and dynamic association helping to define loop specificity and maintain proper domain architecture (e.g.."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": " Its binding can be modulated by DNA methylation and other epigenetic marks, which in turn affect local nucleosome positioning and processes such as alternative splicing, where CTCF‐induced RNA polymerase II pausing promotes exon inclusion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, by recruiting cohesin, CTCF reinforces enhancer blocking and insulator activity, thereby contributing to the dynamic regulation of transcription in diverse cellular contexts. Interactions with other transcription factors further integrate CTCF into regulatory networks that balance active and repressive chromatin states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": " Disruption of CTCF function—whether by genetic mutation, altered methylation, or perturbation of its binding dynamics—can destabilize chromatin loops, compromise insulation, and misregulate gene expression, with consequences for development and disease, including cancer and cohesinopathy syndromes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies illustrate that CTCF acts as a master architectural protein whose context‐dependent interactions and dynamic binding properties are critical for linking the linear genome sequence to its functional three‐dimensional organization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "23"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kerstin S Wendt, Keisuke Yoshida, Takehiko Itoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cohesin mediates transcriptional insulation by CCCTC-binding factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06634"}], "href": "https://doi.org/10.1038/nature06634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18235444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18235444"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chin-Tong Ong, Victor G Corces "}, {"type": "b", "children": [{"type": "t", "text": "CTCF: an architectural protein bridging genome topology and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrg3663"}], "href": "https://doi.org/10.1038/nrg3663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24614316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24614316"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Erik Splinter, Helen Heath, Jurgen Kooren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.399506"}], "href": "https://doi.org/10.1101/gad.399506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16951251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16951251"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sreenivasulu Kurukuti, Vijay Kumar Tiwari, Gholamreza Tavoosidana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0600326103"}], "href": "https://doi.org/10.1073/pnas.0600326103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16815976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16815976"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Vania Parelho, Suzana Hadjur, Mikhail Spivakov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cohesins functionally associate with CTCF on mammalian chromosome arms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.01.011"}], "href": "https://doi.org/10.1016/j.cell.2008.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18237772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18237772"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhonghui Tang, Oscar Junhong Luo, Xingwang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.11.024"}], "href": "https://doi.org/10.1016/j.cell.2015.11.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26686651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26686651"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ya Guo, Quan Xu, Daniele Canzio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.07.038"}], "href": "https://doi.org/10.1016/j.cell.2015.07.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26276636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26276636"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Judith H I Haarhuis, Robin H van der Weide, Vincent A Blomen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2017.04.013"}], "href": "https://doi.org/10.1016/j.cell.2017.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28475897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28475897"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gordana Wutz, Csilla Várnai, Kota Nagasaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201798004"}], "href": "https://doi.org/10.15252/embj.201798004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29217591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29217591"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Elzo de Wit, Erica S M Vos, Sjoerd J B Holwerda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF Binding Polarity Determines Chromatin Looping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.09.023"}], "href": "https://doi.org/10.1016/j.molcel.2015.09.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26527277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26527277"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anders S Hansen, Iryna Pustova, Claudia Cattoglio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF and cohesin regulate chromatin loop stability with distinct dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.25776"}], "href": "https://doi.org/10.7554/eLife.25776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28467304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28467304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sanjeev Shukla, Ersen Kavak, Melissa Gregory, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10442"}], "href": "https://doi.org/10.1038/nature10442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21964334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21964334"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yutao Fu, Manisha Sinha, Craig L Peterson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000138"}], "href": "https://doi.org/10.1371/journal.pgen.1000138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18654629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18654629"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Antoni Hurtado, Kelly A Holmes, Caryn S Ross-Innes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXA1 is a key determinant of estrogen receptor function and endocrine response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.730"}], "href": "https://doi.org/10.1038/ng.730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21151129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21151129"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Suzana Hadjur, Luke M Williams, Natalie K Ryan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08079"}], "href": "https://doi.org/10.1038/nature08079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19458616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19458616"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jian Qun Ling, Tao Li, Ji Fan Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1123191"}], "href": "https://doi.org/10.1126/science.1123191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16614224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16614224"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Matthias Merkenschlager, Elphège P Nora "}, {"type": "b", "children": [{"type": "t", "text": "CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Annu Rev Genomics Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1146/annurev-genom-083115-022339"}], "href": "https://doi.org/10.1146/annurev-genom-083115-022339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27089971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27089971"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "William A Flavahan, Yotam Drier, Brian B Liau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulator dysfunction and oncogene activation in IDH mutant gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature16490"}], "href": "https://doi.org/10.1038/nature16490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26700815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26700815"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Eric D Rubio, David J Reiss, Piri L Welcsh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF physically links cohesin to chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0801273105"}], "href": "https://doi.org/10.1073/pnas.0801273105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18550811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18550811"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Tae Hoon Kim, Ziedulla K Abdullaev, Andrew D Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.12.048"}], "href": "https://doi.org/10.1016/j.cell.2006.12.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17382889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17382889"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hani Rayess, Marilene B Wang, Eri S Srivatsan "}, {"type": "b", "children": [{"type": "t", "text": "Cellular senescence and tumor suppressor gene p16."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.27316"}], "href": "https://doi.org/10.1002/ijc.27316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22025288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22025288"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Suresh Cuddapah, Raja Jothi, Dustin E Schones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.082800.108"}], "href": "https://doi.org/10.1101/gr.082800.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19056695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19056695"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Abraham S Weintraub, Charles H Li, Alicia V Zamudio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YY1 Is a Structural Regulator of Enhancer-Promoter Loops."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2017.11.008"}], "href": "https://doi.org/10.1016/j.cell.2017.11.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29224777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29224777"}]}]}]}
Synonyms	MRD21
Proteins	CTCF_HUMAN
NCBI Gene ID	10664
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CTCF has 10,892 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 133 datasets.

Click the + buttons to view associations for CTCF from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CTCF Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CTCF gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CTCF gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CTCF gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CTCF gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CTCF gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CTCF gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CTCF gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving CTCF protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CTCF gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CTCF gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CTCF gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CTCF gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CTCF gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CTCF gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CTCF protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CTCF gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CTCF gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CTCF gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CTCF gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CTCF gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CTCF protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CTCF gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CTCF protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CTCF protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CTCF protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CTCF protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CTCF protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CTCF protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CTCF gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CTCF gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CTCF gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CTCF gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CTCF gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CTCF protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving CTCF gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CTCF gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CTCF gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CTCF gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CTCF gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CTCF gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.