{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOxidative stress is a key driver of retinal pigment epithelium (RPE) damage in age‐related macular degeneration (AMD), and the long noncoding RNA CYLD-AS1 has emerged as an important mediator in this process. Specifically, CYLD-AS1 is upregulated in RPE cells under oxidative conditions, where it negatively affects cell proliferation and mitochondrial function, thereby exacerbating H₂O₂-induced damage. Moreover, CYLD-AS1 modulates the cellular response by altering the expression of NRF2, a central regulator of oxidative stress, as well as components of the proinflammatory NF-κB signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, CYLD-AS1 functions as a molecular sponge for miR-134-5p, a microRNA that orchestrates the activity of both the NRF2 and NF-κB pathways. This interaction not only intensifies oxidative stress and inflammation within the RPE cells but also enhances the proinflammatory potential of exosomes released from these cells. Collectively, these findings position CYLD-AS1 as a promising therapeutic target for counteracting the oxidative and inflammatory mechanisms underlying AMD and related diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Han Du, Zixin Huang, Xin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress-induced lncRNA CYLD-AS1 promotes RPE inflammation via Nrf2/miR-134-5p/NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202200887R"}], "href": "https://doi.org/10.1096/fj.202200887R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36165267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36165267"}]}]}]}