{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Variants at the 10q24.32 locus have been shown to influence the expression of several genes, including the antisense RNA gene CYP17A1‐AS1. In one study examining arsenic metabolism efficiency, the causal SNP rs4919690 was associated with decreased expression of AS3MT and, in a tissue‐specific manner, of CYP17A1‐AS1 among other nearby genes (e.g., BORCS7, NT5C2, and RP11‐724N1.1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although CYP17A1‐AS1 expression was detected in only one tissue type in this context, its coordinated regulation with genes known to modulate arsenic biotransformation suggests that it may play a role—directly or indirectly—in the metabolic handling of environmental toxins.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, integrative genomic analyses that combine genome‐wide association study data with expression quantitative trait loci (eQTL) information have linked noncoding and intergenic regions of 10q24.32 with a range of disease comorbidities and clinical syndromes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, investigations into the genetic architecture of neuropsychiatric conditions, such as schizophrenia, underscore the importance of this genomic region in disease risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Thus, while the precise mechanistic function of CYP17A1‐AS1 remains to be fully elucidated, current evidence indicates that its expression is modulated by genetic variation at 10q24.32. This modulation may contribute to alterations in arsenic metabolism and potentially influence broader molecular pathways implicated in comorbid and neuropsychiatric diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meytal Chernoff, Lin Tong, Kathryn Demanelis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue Types."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/toxsci/kfaa075"}], "href": "https://doi.org/10.1093/toxsci/kfaa075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32433756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32433756"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haiquan Li, Jungwei Fan, Francesca Vitali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-018-0428-9"}], "href": "https://doi.org/10.1186/s12920-018-0428-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30598089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30598089"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhi-Hui Yang, Xin Cai, Na Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a functional 339 bp "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Alu"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " insertion polymorphism in the schizophrenia-associated locus at 10q24.32."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zool Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.24272/j.issn.2095-8137.2020.014"}], "href": "https://doi.org/10.24272/j.issn.2095-8137.2020.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31840948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31840948"}]}]}]}