{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CYP1B1‐AS1 is emerging as a multifunctional long non‐coding RNA implicated in diverse cancer types. In triple‐negative breast cancer, CYP1B1‐AS1 is part of a set of lncRNAs whose expression is upregulated by TGFβ signaling and shows a positive correlation with TGFβ1 levels, suggesting that it may contribute to the TGFβ‐mediated transcriptional reprogramming in these tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioblastoma, CYP1B1‐AS1 was identified as the top survival‐related enhancer RNA with CYP1B1 as its predicted regulatory target; pathway analyses further implicated it in signaling cascades such as TNF and JAK‑STAT, highlighting its potential role in modulating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in lung adenocarcinoma CYP1B1‐AS1 forms part of a redox‐related lncRNA prognostic signature that distinguishes risk subgroups and independently predicts patient survival, underscoring its prognostic biomarker potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, in acute myeloid leukemia, CYP1B1‐AS1 appears as a core component within a competing endogenous RNA network related to the tumor microenvironment; its expression is highly correlated with immune cell infiltration patterns and patient outcomes, further supporting its relevance in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Radhakrishnan Vishnubalaji, Nehad M Alajez "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-94514-9"}], "href": "https://doi.org/10.1038/s41598-021-94514-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34326372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34326372"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tao Ye, Lan-Lan Li, Xue-Mei Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CYP1B1-AS1 Is a Novel Biomarker in Glioblastoma by Comprehensive Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8565943"}], "href": "https://doi.org/10.1155/2021/8565943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35003394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35003394"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Ren, Aman Wang, Jiwei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of a novel redox-related lncRNA prognostic signature in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1951522"}], "href": "https://doi.org/10.1080/21655979.2021.1951522"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34338158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34338158"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yaqi Cheng, Xiaoran Wang, Peiyan Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor Microenvironmental Competitive Endogenous RNA Network and Immune Cells Act as Robust Prognostic Predictor of Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.584884"}], "href": "https://doi.org/10.3389/fonc.2021.584884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33898304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33898304"}]}]}]}