{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNAs (lncRNAs) have emerged as versatile regulators of gene expression through interactions with proteins, chromatin, and other RNAs, thereby influencing transcription, enhancer activity, and epigenetic states in both normal development and disease processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In the context of cancer, several studies have demonstrated that dysregulated lncRNA expression is strongly associated with tumorigenesis, disease progression, and patient prognosis. A recent investigation addressing gastric carcinoma identified a three‐lncRNA signature that included CYP4A22‑AS1, AP000695.6, and RP11‑108M12.3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Within this prognostic model, CYP4A22‑AS1 carries a negative coefficient, indicating that higher expression levels of this lncRNA are associated with lower risk scores and improved overall survival. Moreover, pathway analysis pointed to the Hippo signaling cascade as a major pathway linked to the signature, suggesting that CYP4A22‑AS1 may contribute to tumor suppression by modulating cell proliferation and survival signals. These results not only reinforce the diverse regulatory functions of lncRNAs but also highlight the potential of CYP4A22‑AS1 as a clinically relevant biomarker and therapeutic target in gastric carcinoma.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Franck Morceau, Sébastien Chateauvieux, Anthoula Gaigneaux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long and short non-coding RNAs as regulators of hematopoietic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms140714744"}], "href": "https://doi.org/10.3390/ijms140714744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23860209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23860209"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David H Taylor, Erin Tsi-Jia Chu, Roman Spektor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA regulation of reproduction and development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.22581"}], "href": "https://doi.org/10.1002/mrd.22581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26517592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26517592"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Emily J Shields, Ana F Petracovici, Roberto Bonasio "}, {"type": "b", "children": [{"type": "t", "text": "lncRedibly versatile: biochemical and biological functions of long noncoding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20180440"}], "href": "https://doi.org/10.1042/BCJ20180440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30971458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30971458"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Denise Thiel, Nataša Djurdjevac Conrad, Evgenia Ntini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-019-2900-8"}], "href": "https://doi.org/10.1186/s12859-019-2900-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31142264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31142264"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peng Cheng "}, {"type": "b", "children": [{"type": "t", "text": "A prognostic 3-long noncoding RNA signature for patients with gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27195"}], "href": "https://doi.org/10.1002/jcb.27195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30074647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30074647"}]}]}]}