| HGNC Family | Cytochrome P450s (CYP) |
| Name | cytochrome P450, family 4, subfamily Z, polypeptide 2, pseudogene |
| Description | Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that the pseudogene CYP4Z2P plays a critical regulatory role in breast cancer by acting as a competitive endogenous RNA (ceRNA). Its 3′UTR shares several miRNA‐binding sites with the functional gene CYP4Z1, thereby sequestering miRNAs (such as miR‐211, miR‐125a-3p, miR‐197, miR‐1226, and miR‐204) and alleviating the miRNA‐mediated repression of CYP4Z1. This ceRNA interplay leads to enhanced CYP4Z1 translation and the subsequent activation of signaling pathways including PI3K/Akt and ERK1/2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAugmented expression of the CYP4Z2P 3′UTR also contributes to tumor angiogenesis. Ectopic expression of this pseudogene segment increases the levels of angiogenic factors, notably VEGF-A, which in turn stimulates endothelial cell proliferation, migration, and tube formation via elevated VEGFR2 expression. These paracrine effects underscore its role in promoting angiogenesis in the breast cancer microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to facilitating angiogenesis, the CYP4Z2P/CYP4Z1 ceRNA network is implicated in other malignant phenotypes. Downregulation of either CYP4Z1 or the CYP4Z2P 3′UTR has been shown to promote cell apoptosis through modulation of hTERT expression, thereby protecting cancer cells from programmed cell death. Moreover, this regulatory axis is associated with tamoxifen resistance and may influence the stemness of breast cancer cells, broadening its impact on tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lufeng Zheng, Xiaoman Li, Yi Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-015-3298-2"}], "href": "https://doi.org/10.1007/s10549-015-3298-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25701119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25701119"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lufeng Zheng, Xiaoman Li, Yi Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pseudogene CYP4Z2P 3'UTR promotes angiogenesis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.09.112"}], "href": "https://doi.org/10.1016/j.bbrc.2014.09.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25281903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25281903"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cheng Li, Lufeng Zheng, Yu Xin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12608"}], "href": "https://doi.org/10.1002/1873-3468.12608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28236635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28236635"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lufeng Zheng, Qianqian Guo, Chenxi Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-019-0697-6"}], "href": "https://doi.org/10.1186/s13045-019-0697-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30832689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30832689"}]}]}]}
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| Proteins | CP4Z2_HUMAN |
| NCBI Gene ID | 163720 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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CYP4Z2P has 1,244 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 26 datasets.
Click the + buttons to view associations for CYP4Z2P from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of CYP4Z2P gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of CYP4Z2P gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of CYP4Z2P gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of CYP4Z2P gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CYP4Z2P gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of CYP4Z2P gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at CYP4Z2P gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CYP4Z2P gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of CYP4Z2P gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing CYP4Z2P from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of CYP4Z2P gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of CYP4Z2P gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of CYP4Z2P gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of CYP4Z2P gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of CYP4Z2P gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CYP4Z2P gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with CYP4Z2P gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with CYP4Z2P gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with CYP4Z2P gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for CYP4Z2P from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of CYP4Z2P gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of CYP4Z2P gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of CYP4Z2P gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for CYP4Z2P from the Pathway Commons Protein-Protein Interactions dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of CYP4Z2P gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of CYP4Z2P gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
