{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies focusing on reproductive barriers in the house mouse subspecies have revealed a finely mapped 150 kb genomic region on chromosome 11 that exhibits elevated sequence differentiation and reduced introgression between Mus musculus musculus and M. m. domesticus. Within this region, one uncharacterized gene––originally annotated as 1700093K21Rik and now referred to as CYP51A1‑AS1––has been identified. Its location in a genomic segment associated with hybrid male sterility suggests that the gene might be involved in reproductive isolation mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Studies of CYP51A1‑AS1 have revealed several distinguishing features: it is expressed specifically in spermatogenic cells, exhibits a high rate of molecular evolution, and harbors a subspecies-specific amino acid variant that gives rise to a structural difference in the protein product. These characteristics indicate that CYP51A1‑AS1 may mediate maladaptive genetic interactions contributing to hybrid male infertility, ultimately reinforcing reproductive barriers between the subspecies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David H Kass, Václav Janoušek, Liuyang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The uncharacterized gene 1700093K21Rik and flanking regions are correlated with reproductive isolation in the house mouse, Mus musculus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-014-9506-2"}], "href": "https://doi.org/10.1007/s00335-014-9506-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24549580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24549580"}]}]}]}