{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CYRIA (CYFIP‑related Rac interactor), also known as Fam49, is an evolutionarily conserved protein that functions as a key regulator of actin‐based membrane protrusions. By binding to activated Rac1 through its DUF1394 domain—a module shared with CYFIP—CYRIA restricts the extent and duration of Scar/WAVE–mediated actin polymerization at the cell edge. Loss of CYRIA leads to the formation of broad, long‐lived lamellipodia and abnormally persistent pseudopods, whereas its overexpression suppresses the recruitment of active Scar/WAVE complexes, resulting in shorter and more transient protrusions. In this way, CYRIA acts as a “local inhibitor” that sharpens protrusion signals, thereby modulating chemotaxis, cell migration, and epithelial polarization. This regulatory mechanism is crucial for ensuring precise control of cell shape and motility in both normal physiological contexts and disease states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Loic Fort, José Miguel Batista, Peter A Thomason, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fam49/CYRI interacts with Rac1 and locally suppresses protrusions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-018-0198-9"}], "href": "https://doi.org/10.1038/s41556-018-0198-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30250061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30250061"}]}]}]}