{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Comprehensive characterization of the human CYYR1 locus has revealed a complex multi‐transcript system. In addition to multiple alternatively spliced CYYR1 isoforms, researchers identified a long antisense transcript—designated CYYR1‑AS1—that overlaps the coding region of CYYR1 and is likely a non‐coding RNA. Expression analyses across normal tissues, tumor cell lines, and fibroblasts (both trisomy 21 and euploid) demonstrated notable quantitative and qualitative variability in the expression of these transcripts, suggesting that the CYYR1/CYYR1‑AS1 locus may play a role in modulating gene expression and contribute to the biology of complex diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Raffaella Casadei, Maria Chiara Pelleri, Lorenza Vitale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of human gene locus CYYR1: a complex multi-transcript system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-014-3480-3"}], "href": "https://doi.org/10.1007/s11033-014-3480-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24981926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24981926"}]}]}]}