{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genome‐wide investigations into subclinical interstitial lung disease have highlighted a candidate locus—D21S2088E—that may contribute to disease pathogenesis. In a large multi‐ethnic study assessing lung densitometry using high attenuation areas (HAA) on CT scans, genomic analyses identified regions suggesting that alterations in protein glycosylation and deregulation of the cell cycle, mediated in part by long non‐coding RNA mechanisms, may be important in disease development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the specific mechanistic details remain to be fully elucidated, D21S2088E appears to be functionally linked to these pathways. In this context, D21S2088E is hypothesized to influence the processes of protein glycosylation as well as the regulation of cell cycle checkpoints. Such roles suggest that dysregulation at this locus could lead to cell cycle disinhibition, thereby contributing to the lung tissue remodeling and interstitial changes observed in early ILD.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings position D21S2088E as a potential molecular player in ILD pathogenesis, warranting further investigation into its role in modulating key cellular processes that underlie the development and progression of this disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ani Manichaikul, Xin-Qun Wang, Li Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of subclinical interstitial lung disease in MESA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12931-017-0581-2"}], "href": "https://doi.org/10.1186/s12931-017-0581-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28521775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28521775"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Zhang, Chang Zou, Chenzhi Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Linc00308/D21S2088E Intergenic Region ALK Fusion and Its Enduring Clinical Responses to Crizotinib."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thorac Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jtho.2020.03.009"}], "href": "https://doi.org/10.1016/j.jtho.2020.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32217130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32217130"}]}]}]}