{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DAPK1‐IT1 is a long noncoding RNA that has emerged as an important regulator in disease contexts characterized by abnormal lipid metabolism and inflammation. In atherosclerosis, DAPK1‐IT1 has been shown to promote the expression of lipoprotein lipase (LPL) by sponging microRNA hsa‐miR‐590‐3p, thereby contributing to dysregulated cholesterol metabolism and enhancing the inflammatory response in macrophages. This axis is associated with altered lipid profiles—including reduced HDL‐C and elevated LDL‐C/VLDL‐C—and ultimately drives atherogenic processes in relevant in vivo models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, DAPK1‐IT1 has been identified as one of the key long noncoding RNAs within a competing endogenous RNA network in asthma, suggesting a role in the modulation of chronic airway inflammation and indicating its potential utility as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, studies in coronary heart disease and atherosclerosis have implicated DAPK1‐IT1 among other lncRNAs in the regulation of cholesterol efflux—modulating the expression of critical transporters such as ABCA1—which underscores its broader relevance in cardiovascular pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that DAPK1‐IT1 acts as a multifunctional mediator that links lipid dysregulation with inflammatory signaling across different diseases, providing a promising target for future therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zigang Zhen, Shaohua Ren, Hongming Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA DAPK-IT1 regulates cholesterol metabolism and inflammatory response in macrophages and promotes atherogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.06.113"}], "href": "https://doi.org/10.1016/j.bbrc.2019.06.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31300197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31300197"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yifang Liao, Ping Li, Yanxia Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of asthma related competing endogenous RNA network revealed novel long non-coding RNAs and potential new drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12931-019-1257-x"}], "href": "https://doi.org/10.1186/s12931-019-1257-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31924195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31924195"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shun Zhang, Lu Li, Jie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2021.01.019"}], "href": "https://doi.org/10.1016/j.cca.2021.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33545111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33545111"}]}]}]}