{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nDARS1‐AS1 is a long non‐coding RNA frequently upregulated in various cancers where it functions as an oncogenic regulator. In clear cell renal cell carcinoma, DARS1‐AS1 promotes tumor progression by sponging miR‐194-5p to upregulate its neighboring gene DARS, thereby enhancing proliferation and inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In thyroid cancer, similar oncogenic behavior has been suggested through the regulation of microRNA-129."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other tumor types, DARS1‐AS1 has been implicated in modulating multiple downstream effectors and signaling cascades. In cervical cancer, one study demonstrated that hypoxia-induced HIF1α elevates DARS1‐AS1 levels to facilitate cytoprotective autophagy by promoting DARS translation via METTL3/METTL14 recruitment"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while another report in cervical cancer highlighted its role in activating the cGMP-PKG pathway via modulation of ATP1B2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In hepatocellular carcinoma, DARS1‐AS1 acts as a competing endogenous RNA by sequestering miR-3200-5p, thereby upregulating CKAP2 and activating the FAK-ERK pathway to promote proliferation, migration, and epithelial-mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, lung adenocarcinoma cells rely on a DARS1‐AS1/miR-188-5p/KLF12 axis to trigger the PI3K/AKT pathway, augmenting cell growth, invasion, and migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in non-small cell lung cancer, a DARS1‐AS1/miR-302a-3p/ACAT1 regulatory network also supports malignant behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these cancers, DARS1‐AS1 has been shown to be crucial in glioblastoma by interacting with YBX1 to stabilize key mRNAs—including E2F1, CCND1, and FOXM1—that drive cell cycle progression, stemness, and DNA repair, thereby contributing to radioresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In acute myeloid leukemia, a regulatory network involving DARS1‐AS1, miR-425, and transforming growth factor-beta 1 (TGFB1) supports leukemogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Although its functions in ovarian cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", further aspects of cervical cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and osteosarcoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "require additional investigation, a recent comprehensive review underscores the pervasive and critical role of DARS1‐AS1 in cancer by orchestrating diverse ceRNA networks, modulating target mRNA stability, and contributing to therapy resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Min Jiao, Hui Guo, Yule Chen, et al. 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