{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Early investigations into the epigenetic consequences of early childhood malnutrition have revealed long‐lasting modifications in the blood DNA methylome that are associated with later deficits in attention and cognition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a related study on Alzheimer’s disease (AD), a competitive endogenous RNA (ceRNA) network was defined that highlighted immune‐related pathways in AD pathogenesis. Within this network, the long noncoding RNA DCTN1‑AS1 was identified as a key regulatory molecule that, along with LINC00836, modulates central hub genes including B2M, FYN, PIK3R1, and PIK3CA. These hub genes are implicated in the immune phenomena associated with AD, suggesting that DCTN1‑AS1 may contribute to regulating immune responses during AD progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings underscore the importance of both epigenetic and ceRNA‐mediated mechanisms in neurodevelopmental and neurodegenerative disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cyril J Peter, Laura K Fischer, Marija Kundakovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2016.03.2100"}], "href": "https://doi.org/10.1016/j.biopsych.2016.03.2100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27184921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27184921"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Xu, Jianping Jia "}, {"type": "b", "children": [{"type": "t", "text": "Immune-Related Hub Genes and the Competitive Endogenous RNA Network in Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-200081"}], "href": "https://doi.org/10.3233/JAD-200081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32925027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32925027"}]}]}]}