DCTN6 Gene

HGNC Family	Dynactin (DCTN)
Name	dynactin 6
Description	The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Dynactin subunit 6 (DCTN6) is emerging as a multifunctional component of the dynactin complex that plays several key roles in intracellular trafficking. In neuronal cells, DCTN6 interacts with the N‐terminal domain of RTN3 to mediate retrograde transport of tubular endoplasmic reticulum along axons; deficiency of DCTN6 leads to impaired ER trafficking and the abnormal accumulation of RTN3‐immunoreactive dystrophic neurites, an event linked to aging and Alzheimer’s disease pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, DCTN6 serves as a binding partner for the envelope glycoprotein E2 of classical swine fever virus; disruption of this interaction attenuates viral replication and virulence, suggesting that DCTN6 is co‐opted by the virus to efficiently support its lifecycle."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in the nervous system and infection, DCTN6 has been implicated as a useful biomarker in oncological contexts. Its mRNA expression levels contribute to prognostic signatures in ovarian cancer, while high expression of DCTN6 in cutaneous melanoma is associated with favorable overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In another context, DCTN6 has been identified as a critical interactor of key regulators of protein trafficking. It binds to the transmembrane protein TMEPAI and is required for proper lysosomal targeting of TMEPAI; deletion of the DCTN6 binding domain redirects TMEPAI to the plasma membrane, underscoring the importance of DCTN6 within the endo‐lysosomal transport machinery."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, interaction studies have revealed that DCTN6 associates with Rab41/6d—a small GTPase involved in Golgi organization—to maintain the integrity of the Golgi ribbon structure. Depletion of DCTN6 results in fragmented Golgi apparatus, indicating its functional role in membrane trafficking and organelle positioning."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Evolutionary analyses further support the conserved nature of DCTN6 as an integral constituent of the dynactin complex, which is pivotal for dynein-mediated cargo movement in eukaryotic cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Md Golam Sharoar, John Zhou, Marc Benoit, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2021.07.006"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2021.07.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34371284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34371284"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "M V Borca, E A Vuono, E Ramirez-Medina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Glycoprotein E2 of Classical Swine Fever Virus Interacts with Host Protein Dynactin Subunit 6 (DCTN6) during the Virus Infectious Cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01642-19"}], "href": "https://doi.org/10.1128/JVI.01642-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31597779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31597779"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chen Zhao, Kewei Xiong, Fangrui Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glycosylation-Related Genes Predict the Prognosis and Immune Fraction of Ovarian Cancer Patients Based on Weighted Gene Coexpression Network Analysis (WGCNA) and Machine Learning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/3665617"}], "href": "https://doi.org/10.1155/2022/3665617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35281472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35281472"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qiaoqi Wang, Xiangkun Wang, Qian Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Value of Dynactin mRNA Expression in Cutaneous Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.910566"}], "href": "https://doi.org/10.12659/MSM.910566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29864111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29864111"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shenheng Luo, Lei Jing, Tian Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep42668"}], "href": "https://doi.org/10.1038/srep42668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28218281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28218281"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shijie Liu, Waqar Majeed, Tetyana Kudlyk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Rab41/6d Effectors Provides an Explanation for the Differential Effects of Rab41/6d and Rab6a/a' on Golgi Organization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2016.00013"}], "href": "https://doi.org/10.3389/fcell.2016.00013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26973836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26973836"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Björn Hammesfahr, Martin Kollmar "}, {"type": "b", "children": [{"type": "t", "text": "Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Evol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2148-12-95"}], "href": "https://doi.org/10.1186/1471-2148-12-95"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22726940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22726940"}]}]}]}
Synonyms	WS-3
Proteins	DCTN6_HUMAN
NCBI Gene ID	10671
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DCTN6 has 5,759 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for DCTN6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DCTN6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCTN6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCTN6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DCTN6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DCTN6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DCTN6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCTN6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving DCTN6 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DCTN6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCTN6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCTN6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DCTN6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCTN6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DCTN6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DCTN6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DCTN6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCTN6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DCTN6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DCTN6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DCTN6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DCTN6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DCTN6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DCTN6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DCTN6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DCTN6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DCTN6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DCTN6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCTN6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DCTN6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DCTN6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DCTN6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DCTN6 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DCTN6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DCTN6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DCTN6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DCTN6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DCTN6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCTN6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DCTN6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DCTN6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DCTN6 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.