DDR1 Gene

HGNC Family	CD molecules (CD), Receptor kinases
Name	discoidin domain receptor tyrosine kinase 1
Description	Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds interstitial collagens and orchestrates a broad range of cellular responses through regulation of adhesion, migration, survival, and extracellular matrix remodeling. DDR1 is aberrantly up‐regulated in various cancers – including ovarian carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", breast and prostate cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and non–small cell lung cancer (NSCLC)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "– where its activation contributes to tumor cell invasion and metastatic dissemination. In lung cancer, for instance, high DDR1 expression correlates with enhanced cell motility, increased matrix metalloproteinase activity, and bone colonization"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", whereas in NSCLC overall expression has been linked with favorable patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In hepatocellular carcinoma, DDR1 is directly targeted by miR‐199a‐5p, and its increased activity is associated with enhanced invasive properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Furthermore, DDR1 functions as a p53 transcriptional target that, upon DNA damage, engages the MAPK cascade in a Ras‐dependent manner, thereby participating in a feed‐forward loop that modulates cell survival and stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in malignancy, DDR1 is critical for mediating cell–matrix interactions in diverse tissue contexts. In skin, DDR1—which is induced by CCN3 from adjacent keratinocytes—promotes melanocyte adhesion to collagen type IV in the basement membrane and is essential for maintaining proper epidermal localization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In mesangial cells, DDR1 not only facilitates firm adhesion to collagen but also modulates cell proliferation by influencing MAPK signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " At the mechanistic level, DDR1 exists as stable, ligand‐independent dimers on the cell surface; however, its transmembrane leucine zipper motif is required for collagen‐induced activation and subsequent downstream signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the vascular system, DDR1 expressed by smooth muscle cells contributes to cell migration and extracellular matrix turnover, influencing pathological processes such as atherosclerosis and lymphangioleiomyomatosis by regulating collagen expression and matrix metalloproteinase production"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and by promoting leukocyte recruitment via chemokine induction in macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Consistent with these roles, deletion of DDR1 in animal models of renal injury—including Alport syndrome and unilateral ureteral obstruction—leads to decreased inflammatory cell infiltration, reduced pro-fibrotic signaling, and diminished matrix deposition, thereby ameliorating renal fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, in hormone-refractory prostate cancer, an axis involving the prostate cancer antigen PCA-1 up-regulates DDR1 expression, which in turn enhances cell invasion through matrix metalloproteinase-9 activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", while in atherosclerotic lesions, DDR1 additionally contributes to plaque development by modulating extracellular matrix composition and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings establish DDR1 as a pivotal mediator of cell–matrix communication that governs cellular adhesion, migration, survival, and tissue remodeling in both physiological and pathological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Viola A Heinzelmann-Schwarz, Margaret Gardiner-Garden, Susan M Henshall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-04-0073"}], "href": "https://doi.org/10.1158/1078-0432.CCR-04-0073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15240533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15240533"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hua Gao, Goutam Chakraborty, Zhanguo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.06.009"}], "href": "https://doi.org/10.1016/j.cell.2016.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27368100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27368100"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sun Ho Yang, Hyun Ah Baek, Ho Jin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or_00000861"}], "href": "https://doi.org/10.3892/or_00000861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20596615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20596615"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Karmele Valencia, Cristina Ormazábal, Carolina Zandueta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-11-1686"}], "href": "https://doi.org/10.1158/1078-0432.CCR-11-1686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22223527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22223527"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "C E Ford, S K Lau, C Q Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6603614"}], "href": "https://doi.org/10.1038/sj.bjc.6603614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17299390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17299390"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qingli Shen, Vito R Cicinnati, Xiaoyong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-9-227"}], "href": "https://doi.org/10.1186/1476-4598-9-227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20799954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20799954"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pat P Ongusaha, Jong-il Kim, Li Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg129"}], "href": "https://doi.org/10.1093/emboj/cdg129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12628922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12628922"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mizuho Fukunaga-Kalabis, Gabriela Martinez, Zhao-Jun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200602132"}], "href": "https://doi.org/10.1083/jcb.200602132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17101694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17101694"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Cyrile A Curat, Wolfgang F Vogel "}, {"type": "b", "children": [{"type": "t", "text": "Discoidin domain receptor 1 controls growth and adhesion of mesangial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.asn.0000032419.13208.0c"}], "href": "https://doi.org/10.1097/01.asn.0000032419.13208.0c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12397034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12397034"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nafeesa A Noordeen, Federico Carafoli, Erhard Hohenester, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M603233200"}], "href": "https://doi.org/10.1074/jbc.M603233200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16774916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16774916"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nicola Ferri, Neil O Carragher, Elaine W Raines "}, {"type": "b", "children": [{"type": "t", "text": "Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)63716-9"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "63716-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15111304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15111304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Guangpei Hou, Wolfgang F Vogel, Michelle P Bendeck "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.res.0000022166.74073.f8"}], "href": "https://doi.org/10.1161/01.res.0000022166.74073.f8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12065315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12065315"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wataru Matsuyama, Lihua Wang, William L Farrar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.4.2332"}], "href": "https://doi.org/10.4049/jimmunol.172.4.2332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14764702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14764702"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Oliver Gross, Rainer Girgert, Bogdan Beirowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2010.03.002"}], "href": "https://doi.org/10.1016/j.matbio.2010.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20307660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20307660"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dominique Guerrot, Monique Kerroch, Sandrine Placier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2011.03.023"}], "href": "https://doi.org/10.1016/j.ajpath.2011.03.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21640971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21640971"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2007.00655.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2007.00655.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17970783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17970783"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Christopher Franco, Guangpei Hou, Pamela J Ahmad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.170662"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.170662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18451340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18451340"}]}]}]}
Synonyms	DDR, MCK10, CD167, NTRK4, TRKE, EDDR1, HGK2, PTK3A, CAK, PTK3, NEP, RTK6
Proteins	DDR1_HUMAN
NCBI Gene ID	780
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DDR1 has 8,690 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 125 datasets.

Click the + buttons to view associations for DDR1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DDR1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDR1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDR1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DDR1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DDR1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DDR1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDR1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DDR1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDR1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDR1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DDR1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDR1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DDR1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with DDR1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DDR1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DDR1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDR1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DDR1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DDR1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DDR1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DDR1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DDR1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DDR1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DDR1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDR1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DDR1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DDR1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DDR1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DDR1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DDR1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DDR1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DDR1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DDR1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DDR1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DDR1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DDR1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for DDR1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DDR1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDR1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DDR1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DDR1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.