DDX24 Gene

HGNC Family	DEAD box polypeptides (DDX)
Name	DEAD (Asp-Glu-Ala-Asp) box helicase 24
Description	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>DDX24 Functions in Immunity, Viral Replication, and Cellular Homeostasis</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n DDX24 is a multifunctional DEAD‐box RNA helicase whose emerging roles span diverse cellular processes and disease contexts. In innate immunity, DDX24 functions as a negative regulator of retinoic acid–inducible gene I (RIG‐I)–like receptor signaling by preferentially binding RNA and associating with adaptor proteins such as FADD and RIP1 to impede the activity of IRF7, thereby tempering type I interferon responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of viral replication, DDX24 is exploited by HIV‐1: experimental depletion of DDX24 diminishes HIV‐1 RNA packaging and infectivity during the Rev-dependent nuclear export process, suggesting that DDX24 normally acts during early RNA metabolism to ensure efficient virion assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its roles in innate immunity and viral replication, DDX24 modulates critical tumor suppressor pathways. By directly binding to the transcriptional co-activator p300, DDX24 suppresses p300-mediated acetylation of p53. Consequently, knockdown of DDX24 enhances p53 acetylation, leading to increased expression of downstream targets and the induction of cell cycle arrest and senescence in cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n Similarly, proteomic studies have shown that DDX24 is also a target of the deubiquitylating enzyme USP7, linking its stability to broader regulatory networks in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent clinical studies have further expanded the spectrum of DDX24’s influence. Mutations in DDX24 have been implicated in vascular malformations associated with multiorgan venous and lymphatic defect (MOVLD) syndrome, with knockdown in endothelial cells leading to increased migration and tube formation – a disturbance in endothelial homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In osteosarcoma, elevated DDX24 expression has been identified as a prognostic factor, underscoring its potential as a biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, phage display–based antigen screening in patients with multiple sclerosis identified DDX24 as a frequently isolated autoantigen candidate, suggesting that its dysregulation might contribute to neuroinflammatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, in Kawasaki disease, higher DDX24 mRNA levels have been associated with coronary artery lesion formation, potentially linking DDX24 to inflammatory vascular pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight DDX24 as an important regulatory node that exerts a dual influence. On one hand, it modulates innate immune signaling and viral RNA processing, whereas on the other, it impacts tumor suppressor pathways and vascular homeostasis. Its multifaceted roles—as both a facilitator of viral replication and a modulator of oncogenic and inflammatory processes—reflect the complex interplay between RNA metabolism and cellular signaling networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhe Ma, Robert Moore, Xiangxi Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003721"}], "href": "https://doi.org/10.1371/journal.ppat.1003721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24204270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24204270"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing Ma, Liwei Rong, Yongdong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2008.01.025"}], "href": "https://doi.org/10.1016/j.virol.2008.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18289627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18289627"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "D Shi, C Dai, J Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of the p300-p53 interplay by DDX24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.77"}], "href": "https://doi.org/10.1038/onc.2015.77"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25867071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25867071"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anna Georges, Edyta Marcon, Jack Greenblatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Characterization of USP7 Targets in Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-34197-x"}], "href": "https://doi.org/10.1038/s41598-018-34197-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30367141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30367141"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pengfei Pang, Xiaojun Hu, Bin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.30200"}], "href": "https://doi.org/10.1002/hep.30200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30063812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30063812"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bei Li, Long Fang, Baolong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Prognostic RBPs in Osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/15330338211004918"}], "href": "https://doi.org/10.1177/15330338211004918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33754909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33754909"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Andrea Cortini, Sara Bembich, Lorena Marson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel non-myelin biomarkers in multiple sclerosis using an improved phage-display approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0226162"}], "href": "https://doi.org/10.1371/journal.pone.0226162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31805175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31805175"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xinglin Li, Xiaoyun Chen, Jiebing Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.67840"}], "href": "https://doi.org/10.7150/ijms.67840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35370459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35370459"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Rizwan Ullah, Jia Li, Puxian Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEAD/H-box helicases:Anti-viral and pro-viral roles during infections."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virusres.2021.198658"}], "href": "https://doi.org/10.1016/j.virusres.2021.198658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34929216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34929216"}]}]}]}
Proteins	DDX24_HUMAN
NCBI Gene ID	57062
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DDX24 has 7,315 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for DDX24 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DDX24 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DDX24 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX24 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX24 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DDX24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DDX24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DDX24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX24 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX24 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDX24 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDX24 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DDX24 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDX24 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX24 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DDX24 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DDX24 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDX24 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DDX24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DDX24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DDX24 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DDX24 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DDX24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DDX24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DDX24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DDX24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DDX24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DDX24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing DDX24 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDX24 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DDX24 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with DDX24 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DDX24 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DDX24 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DDX24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DDX24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DDX24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DDX24 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDX24 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DDX24 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DDX24 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX24 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.