HGNC Family | Defensins |
Name | defensin, beta 136 |
Description | Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014] |
Synonyms | DEFB137 |
Proteins | DB136_HUMAN |
NCBI Gene ID | 613210 |
API | |
Download Associations | |
Predicted Functions |
|
Co-expressed Genes |
|
Expression in Tissues and Cell Lines |
|
DEFB136 has 432 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 28 datasets.
Click the + buttons to view associations for DEFB136 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of DEFB136 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of DEFB136 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of DEFB136 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of DEFB136 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing DEFB136 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of DEFB136 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with DEFB136 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by DEFB136 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at DEFB136 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of DEFB136 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of DEFB136 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with DEFB136 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing DEFB136 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of DEFB136 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of DEFB136 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GO Biological Process Annotations 2015 | biological processes involving DEFB136 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing DEFB136 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of DEFB136 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of DEFB136 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of DEFB136 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of DEFB136 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain DEFB136 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of DEFB136 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving DEFB136 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways | pathways involving DEFB136 protein from the Reactome Pathways dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at DEFB136 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of DEFB136 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
WikiPathways Pathways 2024 | pathways involving DEFB136 protein from the WikiPathways Pathways 2024 dataset. | |