DENND11 Gene

Name	DENN domain containing 11
Description	Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
NCBI Gene ID	57189
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DENND11 has 1,531 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.

Click the + buttons to view associations for DENND11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DENND11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DENND11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DENND11 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DENND11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DENND11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of DENND11 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DENND11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DENND11 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DENND11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DENND11 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DENND11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of DENND11 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of DENND11 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with DENND11 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of DENND11 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of DENND11 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of DENND11 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of DENND11 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of DENND11 gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of DENND11 gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of DENND11 gene from the RummaGEO Gene Perturbation Signatures dataset.
	Sci-Plex Drug Perturbation Signatures	drug perturbations changing expression of DENND11 gene from the Sci-Plex Drug Perturbation Signatures dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of DENND11 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with DENND11 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.