{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies have integrated long noncoding RNA (lncRNA)–mediated competing endogenous RNA (ceRNA) network analyses in Wilms tumor to identify novel prognostic biomarkers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Within these networks, DENND5B‐AS1 was found to be upregulated in tumor tissues. Its high expression was significantly correlated with advanced tumor stage and poorer overall survival, suggesting that DENND5B‐AS1 may function as an oncogenic lncRNA. Acting as a ceRNA, DENND5B‐AS1 likely sponges specific microRNAs, thereby modulating the expression of messenger RNAs that are involved in cell proliferation and other tumorigenic processes. These findings highlight the potential role of DENND5B‐AS1 in Wilms tumor progression and underscore its promise both as a prognostic biomarker and as a candidate for further molecular investigation targeting the ceRNA regulatory axis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Zhang, Liping Zeng, Qinming Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Wilms Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Control (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1073274820936991"}], "href": "https://doi.org/10.1177/1073274820936991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32597194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32597194"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong Zheng, Bai-Hui Li, Chang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms' Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/4951692"}], "href": "https://doi.org/10.1155/2020/4951692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32149111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32149111"}]}]}]}